Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers
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The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-venous oxygen difference and CBF. Studies were done before and 1 h after i.v. injection of 5 mg propranolol and after three weeks on oral propranolol 80 mg/d for 1 week and 160 mg/d for 2 weeks. Cerebrovascular CO2 reactivity in terms of the A-V oxygen difference was tested on all three occasions during hypercapnia and hyperventilation. CBF, CMRO2 and cerebrovascular CO2 reactivity remained stable both after acute and after 3 weeks of treatment with propranolol.
| Original language | English |
|---|---|
| Journal | European Journal of Clinical Pharmacology |
| Volume | 39 |
| Issue number | 3 |
| Pages (from-to) | 295-7 |
| Number of pages | 3 |
| ISSN | 0031-6970 |
| DOIs | |
| Publication status | Published - 1990 |
- Administration, Oral, Adult, Blood Pressure/drug effects, Cerebrovascular Circulation/drug effects, Dose-Response Relationship, Drug, Female, Heart Rate/drug effects, Humans, Injections, Intravenous, Male, Oxygen/metabolism, Propranolol/administration & dosage, Tomography, Emission-Computed, Single-Photon
Research areas
ID: 275129497