Early detection of Alzheimer's disease using MRI hippocampal texture
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Early detection of Alzheimer's disease using MRI hippocampal texture. / Sørensen, Lauge; Igel, Christian; Hansen, Naja Liv; Osler, Merete; Lauritzen, Martin; Rostrup, Egill; Nielsen, Mads.
In: Human Brain Mapping, Vol. 37, No. 3, 2016, p. 1148-1161.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early detection of Alzheimer's disease using MRI hippocampal texture
AU - Sørensen, Lauge
AU - Igel, Christian
AU - Hansen, Naja Liv
AU - Osler, Merete
AU - Lauritzen, Martin
AU - Rostrup, Egill
AU - Nielsen, Mads
PY - 2016
Y1 - 2016
N2 - Cognitive impairment in patients with Alzheimer's disease (AD) is associated with reduction in hippocampal volume in magnetic resonance imaging (MRI). However, it is unknown whether hippocampal texture changes in persons with mild cognitive impairment (MCI) that does not have a change in hippocampal volume. We tested the hypothesis that hippocampal texture has association to early cognitive loss beyond that of volumetric changes. The texture marker was trained and evaluated using T1-weighted MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, and subsequently applied to score independent data sets from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) and the Metropolit 1953 Danish Male Birth Cohort (Metropolit). Hippocampal texture was superior to volume reduction as predictor of MCI-to-AD conversion in ADNI (area under the receiver operating characteristic curve [AUC] 0.74 vs 0.67; DeLong test, p = 0.005), and provided even better prognostic results in AIBL (AUC 0.83). Hippocampal texture, but not volume, correlated with Addenbrooke's cognitive examination score (Pearson correlation, r = −0.25, p
AB - Cognitive impairment in patients with Alzheimer's disease (AD) is associated with reduction in hippocampal volume in magnetic resonance imaging (MRI). However, it is unknown whether hippocampal texture changes in persons with mild cognitive impairment (MCI) that does not have a change in hippocampal volume. We tested the hypothesis that hippocampal texture has association to early cognitive loss beyond that of volumetric changes. The texture marker was trained and evaluated using T1-weighted MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, and subsequently applied to score independent data sets from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) and the Metropolit 1953 Danish Male Birth Cohort (Metropolit). Hippocampal texture was superior to volume reduction as predictor of MCI-to-AD conversion in ADNI (area under the receiver operating characteristic curve [AUC] 0.74 vs 0.67; DeLong test, p = 0.005), and provided even better prognostic results in AIBL (AUC 0.83). Hippocampal texture, but not volume, correlated with Addenbrooke's cognitive examination score (Pearson correlation, r = −0.25, p
KW - biomarker, classification, early diagnosis, hippocampus, image analysis, machine learning, magnetic resonance imaging, mild cognitive impairment
U2 - 10.1002/hbm.23091
DO - 10.1002/hbm.23091
M3 - Journal article
C2 - 26686837
VL - 37
SP - 1148
EP - 1161
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 3
ER -
ID: 152926457