Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes

Research output: Contribution to journal › Review › Research › peer-review

Standard

Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes. / Reiband, H K; Schmidt, S; Ranjan, Ajenthen; Holst, Jens Juul; Madsbad, S; Nørgaard, K.

In: Diabetes - Metabolism: Research and Reviews (Print Edition), Vol. 31, No. 7, 2015, p. 672-9.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Reiband, HK, Schmidt, S, Ranjan, A, Holst, JJ, Madsbad, S & Nørgaard, K 2015, 'Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes', Diabetes - Metabolism: Research and Reviews (Print Edition), vol. 31, no. 7, pp. 672-9. https://doi.org/10.1002/dmrr.2632

APA

Reiband, H. K., Schmidt, S., Ranjan, A., Holst, J. J., Madsbad, S., & Nørgaard, K. (2015). Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes. Diabetes - Metabolism: Research and Reviews (Print Edition), 31(7), 672-9. https://doi.org/10.1002/dmrr.2632

Vancouver

Reiband HK, Schmidt S, Ranjan A, Holst JJ, Madsbad S, Nørgaard K. Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes. Diabetes - Metabolism: Research and Reviews (Print Edition). 2015; 31(7):672-9. https://doi.org/10.1002/dmrr.2632

Author

Reiband, H K ; Schmidt, S ; Ranjan, Ajenthen ; Holst, Jens Juul ; Madsbad, S ; Nørgaard, K. / Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes. In: Diabetes - Metabolism: Research and Reviews (Print Edition). 2015 ; Vol. 31, No. 7. pp. 672-9.

Bibtex

@article{8e48c0892e9e4dbb98459fb40a9ee90c,
title = "Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes",
abstract = "Intensive insulin treatment in type 1 diabetes reduces the incidence and slows the progression of microvascular and macrovascular complications; however, it is associated with an increased risk of hypoglycaemia and weight gain. In this review, we propose dual-hormone treatment with insulin and glucagon as a method for achieving near normalization of blood glucose levels without increasing hypoglycaemia frequency and weight gain. We briefly summarize glucagon pathophysiology in type 1 diabetes as well as the current applications of glucagon for the treatment of hypoglycaemia. Until now, the use of glucagon has been limited by the need for reconstitution immediately before use, because of instability of the available compounds; however, stabile compounds are soon to be launched and will render long-term intensive dual-hormone treatment in type 1 diabetes possible.",
author = "Reiband, {H K} and S Schmidt and Ajenthen Ranjan and Holst, {Jens Juul} and S Madsbad and K N{\o}rgaard",
note = "Copyright {\textcopyright} 2014 John Wiley & Sons, Ltd.",
year = "2015",
doi = "10.1002/dmrr.2632",
language = "English",
volume = " 31",
pages = "672--9",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
publisher = "Wiley",
number = "7",

}

RIS

TY - JOUR

T1 - Dual-hormone treatment with insulin and glucagon in patients with type 1 diabetes

AU - Reiband, H K

AU - Schmidt, S

AU - Ranjan, Ajenthen

AU - Holst, Jens Juul

AU - Madsbad, S

AU - Nørgaard, K

N1 - Copyright © 2014 John Wiley & Sons, Ltd.

PY - 2015

Y1 - 2015

N2 - Intensive insulin treatment in type 1 diabetes reduces the incidence and slows the progression of microvascular and macrovascular complications; however, it is associated with an increased risk of hypoglycaemia and weight gain. In this review, we propose dual-hormone treatment with insulin and glucagon as a method for achieving near normalization of blood glucose levels without increasing hypoglycaemia frequency and weight gain. We briefly summarize glucagon pathophysiology in type 1 diabetes as well as the current applications of glucagon for the treatment of hypoglycaemia. Until now, the use of glucagon has been limited by the need for reconstitution immediately before use, because of instability of the available compounds; however, stabile compounds are soon to be launched and will render long-term intensive dual-hormone treatment in type 1 diabetes possible.

AB - Intensive insulin treatment in type 1 diabetes reduces the incidence and slows the progression of microvascular and macrovascular complications; however, it is associated with an increased risk of hypoglycaemia and weight gain. In this review, we propose dual-hormone treatment with insulin and glucagon as a method for achieving near normalization of blood glucose levels without increasing hypoglycaemia frequency and weight gain. We briefly summarize glucagon pathophysiology in type 1 diabetes as well as the current applications of glucagon for the treatment of hypoglycaemia. Until now, the use of glucagon has been limited by the need for reconstitution immediately before use, because of instability of the available compounds; however, stabile compounds are soon to be launched and will render long-term intensive dual-hormone treatment in type 1 diabetes possible.

U2 - 10.1002/dmrr.2632

DO - 10.1002/dmrr.2632

M3 - Review

C2 - 25533565

VL - 31

SP - 672

EP - 679

JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

IS - 7

ER -

ID: 132047588