Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987
Research output: Contribution to journal › Journal article › Research › peer-review
The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2%) reports, probable in 989 (89.9%) reports, possible in 50 (4.5%) reports and unclassifiable in four (0.4%) reports. Hepatic injuries accounted for 5.9% of all adverse drug reactions reported, and 14.7% of the lethal adverse drug reactions. A total of 47.2% were classified as acute cytotoxic, 16.2% as acute cholestatic and 26.9% as abnormal hepatic function. In 52 (4.7%) cases the hepatic injury was lethal; only 14 (1.3%) cases were chronic. Halothane accounted for 25% of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected during the last 2 years of the decade. Based on consumption data, the incidence of hepatic injury due to sulindac was estimated to be 18-fold higher than that due to ibuprofen. Paracetamol was reported to induce acute cytotoxic as well as cholestatic reactions in non-alcoholic subjects taking therapeutic doses.
Original language | English |
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Journal | Journal of Internal Medicine |
Volume | 232 |
Issue number | 2 |
Pages (from-to) | 133-138 |
Number of pages | 6 |
ISSN | 0954-6820 |
Publication status | Published - Aug 1992 |
- Adolescent, Adult, Aged, Aged, 80 and over, Alkaline Phosphatase, Child, Child, Preschool, Clinical Enzyme Tests, Denmark, Drug-Induced Liver Injury, Female, Humans, Infant, Liver Diseases, Liver Function Tests, Male, Middle Aged, Transaminases
Research areas
ID: 119653605