Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies
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Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies. / Grandjean, Philippe; Meddis, Alessandra; Nielsen, Flemming; Beck, Iben H; Bilenberg, Niels; Goodman, Carly V; Hu, Howard; Till, Christine; Budtz-Jørgensen, Esben.
In: European Journal of Public Health, Vol. 34, No. 1, 2024, p. 143–149.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies
AU - Grandjean, Philippe
AU - Meddis, Alessandra
AU - Nielsen, Flemming
AU - Beck, Iben H
AU - Bilenberg, Niels
AU - Goodman, Carly V
AU - Hu, Howard
AU - Till, Christine
AU - Budtz-Jørgensen, Esben
N1 - Published by Oxford University Press on behalf of the European Public Health Association 2023.
PY - 2024
Y1 - 2024
N2 - BACKGROUND: Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose-effect relationship in greater detail.METHODS: The OCC contributed 837 mother-child pairs to the total of >1500. We measured creatinine-adjusted urine-fluoride concentrations in maternal urine samples obtained during late pregnancy. Child IQ was determined at age 7 years using an abbreviated version of the Wechsler Intelligence Scales for Children. Findings from the three cohorts were used to calculate the joint benchmark concentration (BMC) and the lower confidence limit (BMCL) after adjustment for covariables.RESULTS: In the OCC, urine-fluoride concentrations varied between 0.08 and 3.04 mg/l (median 0.52 mg/l) but were not significantly associated with full-scale IQ at age 7 years (β = 0.08; 95% confidence interval -1.14 to 1.30 for a doubling in exposure). No difference was apparent between boys and girls. In the OCC, the BMC was 0.92 mg/l, with a BMCL of 0.30 mg/l. The joint analysis of all three cohorts showed a statistically significant association between urine-fluoride and IQ, with a BMC of 0.45 mg/l (BMCL, 0.28 mg/l), slightly higher than the BMC previously reported for the two North American cohorts alone.CONCLUSIONS: As the BMCL reflects an approximate threshold for developmental neurotoxicity, the results suggest that pregnant women and children may need protection against fluoride toxicity.
AB - BACKGROUND: Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose-effect relationship in greater detail.METHODS: The OCC contributed 837 mother-child pairs to the total of >1500. We measured creatinine-adjusted urine-fluoride concentrations in maternal urine samples obtained during late pregnancy. Child IQ was determined at age 7 years using an abbreviated version of the Wechsler Intelligence Scales for Children. Findings from the three cohorts were used to calculate the joint benchmark concentration (BMC) and the lower confidence limit (BMCL) after adjustment for covariables.RESULTS: In the OCC, urine-fluoride concentrations varied between 0.08 and 3.04 mg/l (median 0.52 mg/l) but were not significantly associated with full-scale IQ at age 7 years (β = 0.08; 95% confidence interval -1.14 to 1.30 for a doubling in exposure). No difference was apparent between boys and girls. In the OCC, the BMC was 0.92 mg/l, with a BMCL of 0.30 mg/l. The joint analysis of all three cohorts showed a statistically significant association between urine-fluoride and IQ, with a BMC of 0.45 mg/l (BMCL, 0.28 mg/l), slightly higher than the BMC previously reported for the two North American cohorts alone.CONCLUSIONS: As the BMCL reflects an approximate threshold for developmental neurotoxicity, the results suggest that pregnant women and children may need protection against fluoride toxicity.
U2 - 10.1093/eurpub/ckad170
DO - 10.1093/eurpub/ckad170
M3 - Journal article
C2 - 37798092
VL - 34
SP - 143
EP - 149
JO - European Journal of Public Health
JF - European Journal of Public Health
SN - 1101-1262
IS - 1
ER -
ID: 370662164