Dopamine release in ventral striatum of pathological gamblers losing money

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dopamine release in ventral striatum of pathological gamblers losing money. / Linnet, J; Peterson, E; Doudet, D J; Gjedde, A; Møller, A.

In: Acta Psychiatrica Scandinavica, 2010.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Linnet, J, Peterson, E, Doudet, DJ, Gjedde, A & Møller, A 2010, 'Dopamine release in ventral striatum of pathological gamblers losing money', Acta Psychiatrica Scandinavica. https://doi.org/10.1111/j.1600-0447.2010.01591.x

APA

Linnet, J., Peterson, E., Doudet, D. J., Gjedde, A., & Møller, A. (2010). Dopamine release in ventral striatum of pathological gamblers losing money. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/j.1600-0447.2010.01591.x

Vancouver

Linnet J, Peterson E, Doudet DJ, Gjedde A, Møller A. Dopamine release in ventral striatum of pathological gamblers losing money. Acta Psychiatrica Scandinavica. 2010. https://doi.org/10.1111/j.1600-0447.2010.01591.x

Author

Linnet, J ; Peterson, E ; Doudet, D J ; Gjedde, A ; Møller, A. / Dopamine release in ventral striatum of pathological gamblers losing money. In: Acta Psychiatrica Scandinavica. 2010.

Bibtex

@article{ff4af840ac6211df928f000ea68e967b,
title = "Dopamine release in ventral striatum of pathological gamblers losing money",
abstract = "Linnet J, Peterson E, Doudet DJ, Gjedde A, M{\o}ller A. Dopamine release in ventral striatum of pathological gamblers losing money. Objective: To investigate dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as 'chasing one's losses'. We therefore hypothesized that losing money would be associated with increased dopamine release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [(11)C]raclopride to measure dopamine release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased dopamine release in the left ventral striatum compared with HC. PG and HC who won money did not differ in dopamine release. Conclusion: Our findings suggest a dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.",
author = "J Linnet and E Peterson and Doudet, {D J} and A Gjedde and A M{\o}ller",
year = "2010",
doi = "10.1111/j.1600-0447.2010.01591.x",
language = "English",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Dopamine release in ventral striatum of pathological gamblers losing money

AU - Linnet, J

AU - Peterson, E

AU - Doudet, D J

AU - Gjedde, A

AU - Møller, A

PY - 2010

Y1 - 2010

N2 - Linnet J, Peterson E, Doudet DJ, Gjedde A, Møller A. Dopamine release in ventral striatum of pathological gamblers losing money. Objective: To investigate dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as 'chasing one's losses'. We therefore hypothesized that losing money would be associated with increased dopamine release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [(11)C]raclopride to measure dopamine release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased dopamine release in the left ventral striatum compared with HC. PG and HC who won money did not differ in dopamine release. Conclusion: Our findings suggest a dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.

AB - Linnet J, Peterson E, Doudet DJ, Gjedde A, Møller A. Dopamine release in ventral striatum of pathological gamblers losing money. Objective: To investigate dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as 'chasing one's losses'. We therefore hypothesized that losing money would be associated with increased dopamine release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [(11)C]raclopride to measure dopamine release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased dopamine release in the left ventral striatum compared with HC. PG and HC who won money did not differ in dopamine release. Conclusion: Our findings suggest a dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.

U2 - 10.1111/j.1600-0447.2010.01591.x

DO - 10.1111/j.1600-0447.2010.01591.x

M3 - Journal article

C2 - 20712823

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

ER -

ID: 21514790