Does the use of polymethyl-methacrylate cement after intralesional curettage of giant cell tumors of appendicular bone guarantee reduced local recurrence rates? A retrospective analysis
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- Fulltext
Final published version, 610 KB, PDF document
Purpose: Polymethyl-methacrylate cement (PMMA) is often used as bone defect reconstruction material after surgical removal of giant cell tumors. The purpose of this study was to investigate if the application of PMMA improves the local recurrence rates for giant cell tumors (GCT) of appendicular bone treated with intralesional curettage. Methods: A retrospective analysis of all appendicular GTCs treated at two major Danish sarcoma centres between the 1st of January 1998 and December 31st 2013; minimum follow-up of 3.0 years (median: 8.9; 1.3–18.7 years). Kaplan-Meier survival model, log-rank and multivariate Cox regression were used to calculate and compare local recurrence rates. p-values <0.05 were considered statistically significant. Results: 102 patients (M59/F43), median age 31Y (11–84) were included in this study. The overall 3-years local recurrence-rate was 19.9% (95%CI: 11.9–27.9%); 91% had occurred within 3 years. In patients treated with intralesional curettage (n = 64), the 3-years recurrence-rate was 30.6% (95%CI: 18.8–42.4%), compared to 2.6% (95%CI: 0.0–7.8%) in patients treated with wide resection or amputation (n = 38), p <.001. The 3-years recurrence-rate for patients treated with intralesional curettage and reconstruction using PMMA was 29.0% (95%CI: 12.6–45.4%) and without PMMA: 31.8% (95%CI: 15.2–48.4%), p =.83. Conclusion: We found that the use of PMMA for bone defect reconstruction after intralesional curettage of GTCs in the appendicular skeleton did not ensure a reduced risk of local recurrence.
Original language | English |
---|---|
Journal | Journal of Orthopaedic Surgery |
Volume | 31 |
Issue number | 3 |
Number of pages | 6 |
ISSN | 1022-5536 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:
© The Author(s) 2023.
- allograft, bone neoplasm, giant cell tumor of bone, local neoplasm recurrences, polymethyl methacrylate cement
Research areas
ID: 397038732