DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
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- s13148-018-0466-3
Final published version, 648 KB, PDF document
Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
Original language | English |
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Article number | 31 |
Journal | Clinical Epigenetics |
Volume | 10 |
Number of pages | 7 |
ISSN | 1868-7075 |
DOIs | |
Publication status | Published - 2018 |
- BCP-ALL, CIMP, DNA methylation, Prognosis, Relapse, Risk stratification
Research areas
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