Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients
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Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. / Paschos, G K; Magkos, Faidon; Panagiotakos, D B; Votteas, V; Zampelas, Antonis.
In: European Journal of Clinical Nutrition, Vol. 61, No. 10, 2007, p. 1201-1206.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients
AU - Paschos, G K
AU - Magkos, Faidon
AU - Panagiotakos, D B
AU - Votteas, V
AU - Zampelas, Antonis
N1 - (Ekstern)
PY - 2007
Y1 - 2007
N2 - Objective: Alpha-linolenic acid (ALA) is the natural precursor of the cardioprotective long-chain n-3 fatty acids. Available data indicate a possible beneficial effect of ALA on cardiovascular disease (CVD), but the response of various CVD risk factors to increased ALA intake is not well characterized. The purpose of the present study was to examine the effect of increased ALA intake on blood pressure in man. Design, setting, subjects and interventions: We used a prospective, two-group, parallel-arm design to examine the effect of a 12-week dietary supplementation with flaxseed oil, rich in ALA (8 g/day), on blood pressure in middle-aged dyslipidaemic men (n=59). The diet of the control group was supplemented with safflower oil, containing the equivalent n-6 fatty acid (11 g/day linoleic acid (LA); n=28). Arterial blood pressure was measured at the beginning and at the end of the dietary intervention period.Results: Supplementation with ALA resulted in significantly lower systolic and diastolic blood pressure levels compared with LA (P=0.016 and P=0.011, respectively, from analysis of variance (ANOVA) for repeated measures).Conclusions: We observed a hypotensive effect of ALA, which may constitute another mechanism accounting in part for the apparent cardioprotective effect of this n-3 fatty acid.
AB - Objective: Alpha-linolenic acid (ALA) is the natural precursor of the cardioprotective long-chain n-3 fatty acids. Available data indicate a possible beneficial effect of ALA on cardiovascular disease (CVD), but the response of various CVD risk factors to increased ALA intake is not well characterized. The purpose of the present study was to examine the effect of increased ALA intake on blood pressure in man. Design, setting, subjects and interventions: We used a prospective, two-group, parallel-arm design to examine the effect of a 12-week dietary supplementation with flaxseed oil, rich in ALA (8 g/day), on blood pressure in middle-aged dyslipidaemic men (n=59). The diet of the control group was supplemented with safflower oil, containing the equivalent n-6 fatty acid (11 g/day linoleic acid (LA); n=28). Arterial blood pressure was measured at the beginning and at the end of the dietary intervention period.Results: Supplementation with ALA resulted in significantly lower systolic and diastolic blood pressure levels compared with LA (P=0.016 and P=0.011, respectively, from analysis of variance (ANOVA) for repeated measures).Conclusions: We observed a hypotensive effect of ALA, which may constitute another mechanism accounting in part for the apparent cardioprotective effect of this n-3 fatty acid.
KW - Adult
KW - Aged
KW - Analysis of Variance
KW - Blood Pressure/drug effects
KW - Cardiovascular Diseases/prevention & control
KW - Dietary Supplements
KW - Dyslipidemias/complications
KW - Fatty Acids, Omega-3/administration & dosage
KW - Fatty Acids, Omega-6/administration & dosage
KW - Humans
KW - Linoleic Acids/administration & dosage
KW - Linseed Oil/administration & dosage
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Risk Factors
KW - alpha-Linolenic Acid/administration & dosage
U2 - 10.1038/sj.ejcn.1602631
DO - 10.1038/sj.ejcn.1602631
M3 - Journal article
C2 - 17268413
VL - 61
SP - 1201
EP - 1206
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 10
ER -
ID: 297152879