TY - JOUR

T1 - Dietary predictors of perfluorinated chemicals

T2 - A study from the Danish National Birth Cohort

AU - Halldorsson, Thorhallur I.

AU - Fei, Chunyuan

AU - Olsen, Jørn

AU - Lipworth, Loren

AU - Mclaughlin, Joseph K.

AU - Olsen, Sjurdur F.

PY - 2008

Y1 - 2008

N2 - This study investigated the association between dietary variables and plasma levels of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) among 1076 pregnant women. Diet was assessed at midpregnancy by a food-frequency questionnaire. Mean first trimester plasma PFOS and PFOA levels were 35.1 and 5.6 ng/mL, respectively. PFOS levels were positively associated (p < 0.05) with intake of red meat, animal fats, and snacks (e.g., popcorn, potato chips), whereas intake of vegetables and poultry was inversely associated. The adjusted mean differences between the 75th and 25th intake percentiles were 4.3 ng/mL [95% CI: 2.1, 6.5] for red meat, 3.4 ng/mL [95% CI: 1.2, 5.6] for animal fats, and 2.0 ng/mL [95% CI: 0.3, 3.6] for snacks. Similar but weaker associations were observed for PFOA. Furthermore, a comparison between women reporting low (≤25th percentile) red meat and high (≥75th percentile) vegetable intake and women reporting low vegetable and high red meat intake resulted in differences in plasma PFOS and PFOA concentrations equal to 31% and 18% of mean levels, respectively. Studies quantifying levels of perfluorinated compounds in food have suggested that diet could be an important route of human exposure. The observed associations in our study between dietary variables and maternal exposure further support that conclusion.

AB - This study investigated the association between dietary variables and plasma levels of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) among 1076 pregnant women. Diet was assessed at midpregnancy by a food-frequency questionnaire. Mean first trimester plasma PFOS and PFOA levels were 35.1 and 5.6 ng/mL, respectively. PFOS levels were positively associated (p < 0.05) with intake of red meat, animal fats, and snacks (e.g., popcorn, potato chips), whereas intake of vegetables and poultry was inversely associated. The adjusted mean differences between the 75th and 25th intake percentiles were 4.3 ng/mL [95% CI: 2.1, 6.5] for red meat, 3.4 ng/mL [95% CI: 1.2, 5.6] for animal fats, and 2.0 ng/mL [95% CI: 0.3, 3.6] for snacks. Similar but weaker associations were observed for PFOA. Furthermore, a comparison between women reporting low (≤25th percentile) red meat and high (≥75th percentile) vegetable intake and women reporting low vegetable and high red meat intake resulted in differences in plasma PFOS and PFOA concentrations equal to 31% and 18% of mean levels, respectively. Studies quantifying levels of perfluorinated compounds in food have suggested that diet could be an important route of human exposure. The observed associations in our study between dietary variables and maternal exposure further support that conclusion.

U2 - 10.1021/es801907r

DO - 10.1021/es801907r

M3 - Journal article

C2 - 19192827

AN - SCOPUS:57449121629

VL - 42

SP - 8971

EP - 8977

JO - Environmental Science &amp; Technology

JF - Environmental Science &amp; Technology

SN - 0013-936X

IS - 23

ER -