TY - JOUR

T1 - Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020–2030

AU - Zare Jeddi, Maryam

AU - Hopf, Nancy B.

AU - Louro, Henriqueta

AU - Viegas, Susana

AU - Galea, Karen S.

AU - Pasanen-Kase, Robert

AU - Santonen, Tiina

AU - Mustieles, Vicente

AU - Fernandez, Mariana F.

AU - Verhagen, Hans

AU - Bopp, Stephanie K.

AU - Antignac, Jean Philippe

AU - David, Arthur

AU - Mol, Hans

AU - Barouki, Robert

AU - Audouze, Karine

AU - Duca, Radu Corneliu

AU - Fantke, Peter

AU - Scheepers, Paul

AU - Ghosh, Manosij

AU - Van Nieuwenhuyse, An

AU - Lobo Vicente, Joana

AU - Trier, Xenia

AU - Rambaud, Loïc

AU - Fillol, Clémence

AU - Denys, Sebastien

AU - Conrad, André

AU - Kolossa-Gehring, Marike

AU - Paini, Alicia

AU - Arnot, Jon

AU - Schulze, Florian

AU - Jones, Kate

AU - Sepai, Ovnair

AU - Ali, Imran

AU - Brennan, Lorraine

AU - Benfenati, Emilio

AU - Cubadda, Francesco

AU - Mantovani, Alberto

AU - Bartonova, Alena

AU - Connolly, Alison

AU - Slobodnik, Jaroslav

AU - Bruinen de Bruin, Yuri

AU - van Klaveren, Jacob

AU - Palmen, Nicole

AU - Dirven, Hubert

AU - Husøy, Trine

AU - Thomsen, Cathrine

AU - Virgolino, Ana

AU - Röösli, Martin

AU - Gant, Tim

AU - von Goetz, Natalie

AU - Bessems, Jos

N1 - Publisher Copyright: © 2022 The Authors

PY - 2022

Y1 - 2022

N2 - Human biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission's Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemicals (mixtures); (4) bridging regulatory silos on aggregate exposure; and (5) enhancing the effectiveness of risk management measures. In this strategy paper we propose a vision and a strategy for the use of HBM in chemical regulations and public health policy in Europe and beyond. We outline six strategic objectives and a roadmap to further strengthen HBM approaches and increase their implementation in the regulatory risk assessment of chemicals to enhance our understanding of exposure and health impacts, enabling timely and targeted policy interventions and risk management. These strategic objectives are: 1) further development of sampling strategies and sample preparation; 2) further development of chemical-analytical HBM methods; 3) improving harmonisation throughout the HBM research life cycle; 4) further development of quality control / quality assurance throughout the HBM research life cycle; 5) obtain sustained funding and reinforcement by legislation; and 6) extend target-specific communication with scientists, policymakers, citizens and other stakeholders. HBM approaches are essential in risk assessment to address scientific, regulatory and societal challenges. HBM requires full and strong support from the scientific and regulatory domain to reach its full potential in public and occupational health assessment and in regulatory decision-making.

AB - Human biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission's Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemicals (mixtures); (4) bridging regulatory silos on aggregate exposure; and (5) enhancing the effectiveness of risk management measures. In this strategy paper we propose a vision and a strategy for the use of HBM in chemical regulations and public health policy in Europe and beyond. We outline six strategic objectives and a roadmap to further strengthen HBM approaches and increase their implementation in the regulatory risk assessment of chemicals to enhance our understanding of exposure and health impacts, enabling timely and targeted policy interventions and risk management. These strategic objectives are: 1) further development of sampling strategies and sample preparation; 2) further development of chemical-analytical HBM methods; 3) improving harmonisation throughout the HBM research life cycle; 4) further development of quality control / quality assurance throughout the HBM research life cycle; 5) obtain sustained funding and reinforcement by legislation; and 6) extend target-specific communication with scientists, policymakers, citizens and other stakeholders. HBM approaches are essential in risk assessment to address scientific, regulatory and societal challenges. HBM requires full and strong support from the scientific and regulatory domain to reach its full potential in public and occupational health assessment and in regulatory decision-making.

KW - Chemicals mixtures

KW - Circular economy

KW - Data governance

KW - Human biomonitoring

KW - One substance-one assessment

KW - Zero Pollution Ambition

U2 - 10.1016/j.envint.2022.107476

DO - 10.1016/j.envint.2022.107476

M3 - Journal article

C2 - 36067553

AN - SCOPUS:85137301169

VL - 168

JO - Environment international

JF - Environment international

SN - 0160-4120

M1 - 107476

ER -