Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study

Research output: Contribution to journalJournal articleResearchpeer-review

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Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study. / Murphy, Robert P.; Catriona, Reddin; Rosengren, Annika; Judge, Conor; Hankey, Graeme J.; Ferguson, John; Alvarez-Iglesias, Alberto; Oveisgharan, Shahram; Wasay, Mohammad; McDermott, Clodagh; Iversen, Helle Klingenberg; Lanas, Fernando; Al-Hussain, Fawaz; Czlonkowska, Anna; Oguz, Aytekin; Ogunniyi, Adesola; Damasceno, Albertino; Xavier, Denis; Avezum, Alvaro; Wang, Xingyu; Langhorne, Peter; Yusuf, Salim; O'Donnell, Martin; the INTERSTROKE investigators.

In: Neurology, Vol. 100, No. 17, 2023, p. E1787-E1798.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Murphy, RP, Catriona, R, Rosengren, A, Judge, C, Hankey, GJ, Ferguson, J, Alvarez-Iglesias, A, Oveisgharan, S, Wasay, M, McDermott, C, Iversen, HK, Lanas, F, Al-Hussain, F, Czlonkowska, A, Oguz, A, Ogunniyi, A, Damasceno, A, Xavier, D, Avezum, A, Wang, X, Langhorne, P, Yusuf, S, O'Donnell, M & the INTERSTROKE investigators 2023, 'Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study', Neurology, vol. 100, no. 17, pp. E1787-E1798. https://doi.org/10.1212/WNL.0000000000207093

APA

Murphy, R. P., Catriona, R., Rosengren, A., Judge, C., Hankey, G. J., Ferguson, J., Alvarez-Iglesias, A., Oveisgharan, S., Wasay, M., McDermott, C., Iversen, H. K., Lanas, F., Al-Hussain, F., Czlonkowska, A., Oguz, A., Ogunniyi, A., Damasceno, A., Xavier, D., Avezum, A., ... the INTERSTROKE investigators (2023). Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study. Neurology, 100(17), E1787-E1798. https://doi.org/10.1212/WNL.0000000000207093

Vancouver

Murphy RP, Catriona R, Rosengren A, Judge C, Hankey GJ, Ferguson J et al. Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study. Neurology. 2023;100(17):E1787-E1798. https://doi.org/10.1212/WNL.0000000000207093

Author

Murphy, Robert P. ; Catriona, Reddin ; Rosengren, Annika ; Judge, Conor ; Hankey, Graeme J. ; Ferguson, John ; Alvarez-Iglesias, Alberto ; Oveisgharan, Shahram ; Wasay, Mohammad ; McDermott, Clodagh ; Iversen, Helle Klingenberg ; Lanas, Fernando ; Al-Hussain, Fawaz ; Czlonkowska, Anna ; Oguz, Aytekin ; Ogunniyi, Adesola ; Damasceno, Albertino ; Xavier, Denis ; Avezum, Alvaro ; Wang, Xingyu ; Langhorne, Peter ; Yusuf, Salim ; O'Donnell, Martin ; the INTERSTROKE investigators. / Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study. In: Neurology. 2023 ; Vol. 100, No. 17. pp. E1787-E1798.

Bibtex

@article{67562d2c13024f7e8b1b59069fae57b3,
title = "Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study",
abstract = "Background and Objectives Depression has been reported to be a risk factor of acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke type. Methods The INTERSTROKE is an international case-control study of risk factors of first acute stroke, conducted in 32 countries. Cases were patients with CT- or MRI-confirmed incident acute hospitalized stroke, and controls were matched for age, sex, and within sites. Standardized questions asked about self-reported depressive symptoms during the previous 12 months and the use of prescribed antidepressant medications were recorded. Multivariable conditional logistic regression was used to determine the association of prestroke depressive symptoms with acute stroke risk. Adjusted ordinal logistic regression was used to explore the association of prestroke depressive symptoms with poststroke functional outcome, measured with the modified Rankin scale at 1 month after stroke. Results Of 26, 877 participants, 40.4% were women, and the mean age was 61.7 ± 13.4 years. The prevalence of depressive symptoms within the last 12 months was higher in cases compared with that in controls (18.3% vs 14.1%, p < 0.001) and differed by region (p interaction <0.001), with lowest prevalence in China (6.9% in controls) and highest in South America (32.2% of controls). In multivariable analyses, prestroke depressive symptoms were associated with greater odds of acute stroke (odds ratio [OR] 1.46, 95% CI 1.34-1.58), which was significant for both intracerebral hemorrhage (OR 1.56, 95% CI 1.28-1.91) and ischemic stroke (OR 1.44, 95% CI 1.31-1.58). A larger magnitude of association with stroke was seen in patients with a greater burden of depressive symptoms. While preadmission depressive symptoms were not associated with a greater odds of worse baseline stroke severity (OR 1.02, 95% CI 0.94-1.10), they were associated with a greater odds of poor functional outcome at 1 month after acute stroke (OR 1.09, 95% CI 1.01-1.19). Discussion In this global study, we recorded that depressive symptoms are an important risk factor of acute stroke, including both ischemic and hemorrhagic stroke. Preadmission depressive symptoms were associated with poorer functional outcome, but not baseline stroke severity, suggesting an adverse role of depressive symptoms in poststroke recovery.",
author = "Murphy, {Robert P.} and Reddin Catriona and Annika Rosengren and Conor Judge and Hankey, {Graeme J.} and John Ferguson and Alberto Alvarez-Iglesias and Shahram Oveisgharan and Mohammad Wasay and Clodagh McDermott and Iversen, {Helle Klingenberg} and Fernando Lanas and Fawaz Al-Hussain and Anna Czlonkowska and Aytekin Oguz and Adesola Ogunniyi and Albertino Damasceno and Denis Xavier and Alvaro Avezum and Xingyu Wang and Peter Langhorne and Salim Yusuf and Martin O'Donnell and {the INTERSTROKE investigators}",
note = "Publisher Copyright: {\textcopyright} 2023 Lippincott Williams and Wilkins. All rights reserved.",
year = "2023",
doi = "10.1212/WNL.0000000000207093",
language = "English",
volume = "100",
pages = "E1787--E1798",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams & Wilkins",
number = "17",

}

RIS

TY - JOUR

T1 - Depressive Symptoms and Risk of Acute Stroke INTERSTROKE Case-Control Study

AU - Murphy, Robert P.

AU - Catriona, Reddin

AU - Rosengren, Annika

AU - Judge, Conor

AU - Hankey, Graeme J.

AU - Ferguson, John

AU - Alvarez-Iglesias, Alberto

AU - Oveisgharan, Shahram

AU - Wasay, Mohammad

AU - McDermott, Clodagh

AU - Iversen, Helle Klingenberg

AU - Lanas, Fernando

AU - Al-Hussain, Fawaz

AU - Czlonkowska, Anna

AU - Oguz, Aytekin

AU - Ogunniyi, Adesola

AU - Damasceno, Albertino

AU - Xavier, Denis

AU - Avezum, Alvaro

AU - Wang, Xingyu

AU - Langhorne, Peter

AU - Yusuf, Salim

AU - O'Donnell, Martin

AU - the INTERSTROKE investigators

N1 - Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Background and Objectives Depression has been reported to be a risk factor of acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke type. Methods The INTERSTROKE is an international case-control study of risk factors of first acute stroke, conducted in 32 countries. Cases were patients with CT- or MRI-confirmed incident acute hospitalized stroke, and controls were matched for age, sex, and within sites. Standardized questions asked about self-reported depressive symptoms during the previous 12 months and the use of prescribed antidepressant medications were recorded. Multivariable conditional logistic regression was used to determine the association of prestroke depressive symptoms with acute stroke risk. Adjusted ordinal logistic regression was used to explore the association of prestroke depressive symptoms with poststroke functional outcome, measured with the modified Rankin scale at 1 month after stroke. Results Of 26, 877 participants, 40.4% were women, and the mean age was 61.7 ± 13.4 years. The prevalence of depressive symptoms within the last 12 months was higher in cases compared with that in controls (18.3% vs 14.1%, p < 0.001) and differed by region (p interaction <0.001), with lowest prevalence in China (6.9% in controls) and highest in South America (32.2% of controls). In multivariable analyses, prestroke depressive symptoms were associated with greater odds of acute stroke (odds ratio [OR] 1.46, 95% CI 1.34-1.58), which was significant for both intracerebral hemorrhage (OR 1.56, 95% CI 1.28-1.91) and ischemic stroke (OR 1.44, 95% CI 1.31-1.58). A larger magnitude of association with stroke was seen in patients with a greater burden of depressive symptoms. While preadmission depressive symptoms were not associated with a greater odds of worse baseline stroke severity (OR 1.02, 95% CI 0.94-1.10), they were associated with a greater odds of poor functional outcome at 1 month after acute stroke (OR 1.09, 95% CI 1.01-1.19). Discussion In this global study, we recorded that depressive symptoms are an important risk factor of acute stroke, including both ischemic and hemorrhagic stroke. Preadmission depressive symptoms were associated with poorer functional outcome, but not baseline stroke severity, suggesting an adverse role of depressive symptoms in poststroke recovery.

AB - Background and Objectives Depression has been reported to be a risk factor of acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke type. Methods The INTERSTROKE is an international case-control study of risk factors of first acute stroke, conducted in 32 countries. Cases were patients with CT- or MRI-confirmed incident acute hospitalized stroke, and controls were matched for age, sex, and within sites. Standardized questions asked about self-reported depressive symptoms during the previous 12 months and the use of prescribed antidepressant medications were recorded. Multivariable conditional logistic regression was used to determine the association of prestroke depressive symptoms with acute stroke risk. Adjusted ordinal logistic regression was used to explore the association of prestroke depressive symptoms with poststroke functional outcome, measured with the modified Rankin scale at 1 month after stroke. Results Of 26, 877 participants, 40.4% were women, and the mean age was 61.7 ± 13.4 years. The prevalence of depressive symptoms within the last 12 months was higher in cases compared with that in controls (18.3% vs 14.1%, p < 0.001) and differed by region (p interaction <0.001), with lowest prevalence in China (6.9% in controls) and highest in South America (32.2% of controls). In multivariable analyses, prestroke depressive symptoms were associated with greater odds of acute stroke (odds ratio [OR] 1.46, 95% CI 1.34-1.58), which was significant for both intracerebral hemorrhage (OR 1.56, 95% CI 1.28-1.91) and ischemic stroke (OR 1.44, 95% CI 1.31-1.58). A larger magnitude of association with stroke was seen in patients with a greater burden of depressive symptoms. While preadmission depressive symptoms were not associated with a greater odds of worse baseline stroke severity (OR 1.02, 95% CI 0.94-1.10), they were associated with a greater odds of poor functional outcome at 1 month after acute stroke (OR 1.09, 95% CI 1.01-1.19). Discussion In this global study, we recorded that depressive symptoms are an important risk factor of acute stroke, including both ischemic and hemorrhagic stroke. Preadmission depressive symptoms were associated with poorer functional outcome, but not baseline stroke severity, suggesting an adverse role of depressive symptoms in poststroke recovery.

U2 - 10.1212/WNL.0000000000207093

DO - 10.1212/WNL.0000000000207093

M3 - Journal article

C2 - 36889922

AN - SCOPUS:85153803352

VL - 100

SP - E1787-E1798

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 17

ER -

ID: 396397252