Demographic Clinical and Prognostic Factors of Primary Ovarian Adenocarcinomas of Serous and Clear Cell Histology—A Comparative Study
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: To compare clinical demographic and prognostic factors as well as overall survival in a nationwide cohort of patients diagnosed with ovarian clear cell carcinoma (oCCC) and high grade ovarian serous adenocarcinoma (oSAC) during 2005 to 2013.
MATERIALS AND METHODS: Population-based prospectively collected data on oCCC (n = 179) and oSAC (n = 2363) cases were obtained from the Danish Gynecological Cancer Database. χ, Fischer or Wilcoxon-Mann-Whitney, multivariate logistic regression, univariate Kaplan-Meier, and multivariate Cox regression tests were used. Statistical tests were 2-sided. P values less than 0.05 were considered statistically significant.
RESULTS: The oCCC cases were significantly younger than oSAC cases. An inverse association between ever smoking and oCCC as compared to oSAC was observed and a significantly higher proportion of oCCC was found to be nulliparous (odds ratio, 0.62; 95% confidence interval, 0.37-0.92).Although more oSAC than oCCC cases diagnosed in stage III or IV were referred to neoadjuvant chemotherapy, a higher proportion of oCCC achieved complete cytoreduction at primary debulking surgery and/or had lymphadenectomy performed; overall survival were poorer among oCCC than oSAC cases in analyses restricted to stages III and IV (odds ratio, 1.87; 95% confidence interval, 1.35-2.61), whereas no difference between early stage oCCC and oSAC was observed.
CONCLUSIONS: The study confirms that demographic features and risk factors differ between oCCC and oSAC cases. Furthermore, our findings confirm that advanced stages of oCCC have a poorer prognosis compared with oSAC probably because of the resistance toward adjuvant chemotherapy. The observed differences highlight the need for subtype-specific research and individualized treatment within ovarian cancer.
Original language | English |
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Journal | International Journal of Gynecological Cancer |
Volume | 26 |
Issue number | 1 |
Pages (from-to) | 82-90 |
Number of pages | 9 |
ISSN | 1048-891X |
DOIs | |
Publication status | Published - Jan 2016 |
- Adenocarcinoma, Adenocarcinoma, Clear Cell, Aged, Antineoplastic Combined Chemotherapy Protocols, Combined Modality Therapy, Cystadenocarcinoma, Serous, Endometrial Neoplasms, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasm Staging, Ovarian Neoplasms, Prognosis, Prospective Studies, Survival Rate, Comparative Study, Journal Article
Research areas
ID: 176897744