D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria: a focused review
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D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria : a focused review. / Ghazanfar, Misbah Noshela; Thomsen, Simon Francis.
In: European Journal of Dermatology, Vol. 28, No. 6, 2018, p. 731-735.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria
T2 - a focused review
AU - Ghazanfar, Misbah Noshela
AU - Thomsen, Simon Francis
PY - 2018
Y1 - 2018
N2 - Chronic urticaria is an itchy skin disease, which is treated with antihistamines; however, a large group of patients are unresponsive to antihistamines alone and are thus treated with omalizumab, although a small fraction of these patients have particularly recalcitrant disease. Currently, there are no reliable biomarkers available to assess disease activity/severity and treatment response in chronic urticaria patients. However, it has been reported that high levels of d-dimer are observed during disease activity and are significantly reduced during periods of remission. We present a focused overview of studies investigating plasma d-dimer level as a biomarker for disease activity and treatment response in patients with chronic urticaria.
AB - Chronic urticaria is an itchy skin disease, which is treated with antihistamines; however, a large group of patients are unresponsive to antihistamines alone and are thus treated with omalizumab, although a small fraction of these patients have particularly recalcitrant disease. Currently, there are no reliable biomarkers available to assess disease activity/severity and treatment response in chronic urticaria patients. However, it has been reported that high levels of d-dimer are observed during disease activity and are significantly reduced during periods of remission. We present a focused overview of studies investigating plasma d-dimer level as a biomarker for disease activity and treatment response in patients with chronic urticaria.
KW - chronic urticaria
KW - D-dimer
KW - biomarker
KW - disease activity
KW - treatment response
U2 - 10.1684/ejd.2018.3443
DO - 10.1684/ejd.2018.3443
M3 - Review
C2 - 30530404
VL - 28
SP - 731
EP - 735
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 6
ER -
ID: 218088240