Cyanotic congenital heart disease and atherosclerosis
Research output: Contribution to journal › Review › Research › peer-review
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Cyanotic congenital heart disease and atherosclerosis. / Tarp, Julie Bjerre; Jensen, Annette Schophuus; Engstrøm, Thomas; Holstein-Rathlou, Niels-Henrik; Søndergaard, Lars.
In: Heart, Vol. 103, 06.2017, p. 897-900.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Cyanotic congenital heart disease and atherosclerosis
AU - Tarp, Julie Bjerre
AU - Jensen, Annette Schophuus
AU - Engstrøm, Thomas
AU - Holstein-Rathlou, Niels-Henrik
AU - Søndergaard, Lars
N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2017/6
Y1 - 2017/6
N2 - Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing.This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD.
AB - Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing.This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD.
KW - Atherosclerosis
KW - Global Health
KW - Heart Defects, Congenital
KW - Humans
KW - Prevalence
KW - Journal Article
KW - Review
U2 - 10.1136/heartjnl-2016-311012
DO - 10.1136/heartjnl-2016-311012
M3 - Review
C2 - 28259844
VL - 103
SP - 897
EP - 900
JO - Heart
JF - Heart
SN - 1355-6037
ER -
ID: 188159366