C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells
Research output: Contribution to journal › Journal article › Research › peer-review
Replacement of proinsulin C-peptide in type 1 diabetes ameliorates nerve and kidney dysfunction, conditions which are associated with a decrease in Na,K-ATPase activity. We determined the molecular mechanism by which long term exposure to C-peptide stimulates Na,K-ATPase expression and activity in primary human renal tubular cells (HRTC) in control and hyperglycemic conditions.
| Original language | English |
|---|---|
| Journal | P L o S One |
| Volume | 6 |
| Issue number | 12 |
| Pages (from-to) | e28294 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 2011 |
- C-Peptide, Cell Nucleus, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Enzymologic, Gene Silencing, Homeodomain Proteins, Humans, Hyperglycemia, Kidney Tubules, MAP Kinase Signaling System, Models, Biological, Ouabain, Peptides, Phosphorylation, Protein Isoforms, Protein Kinase C, Protein Kinase C-alpha, Protein Kinase C-delta, Protein Kinase C-epsilon, Signal Transduction, Sodium, Sodium-Potassium-Exchanging ATPase, Transcription Factors
Research areas
ID: 45577193