Control of metabolism and growth through insulin-like peptides in Drosophila
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Control of metabolism and growth through insulin-like peptides in Drosophila. / Géminard, Charles; Arquier, Nathalie; Layalle, Sophie; Bourouis, Marc; Slaidina, Maija; Delanoue, Renald; Bjordal, Marianne; Ohanna, Mickael; Ma, May; Colombani, Julien; Léopold, Pierre.
In: Diabetes, Vol. 55, No. SUPPL. 2, 01.12.2006, p. S5-S8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Control of metabolism and growth through insulin-like peptides in Drosophila
AU - Géminard, Charles
AU - Arquier, Nathalie
AU - Layalle, Sophie
AU - Bourouis, Marc
AU - Slaidina, Maija
AU - Delanoue, Renald
AU - Bjordal, Marianne
AU - Ohanna, Mickael
AU - Ma, May
AU - Colombani, Julien
AU - Léopold, Pierre
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Insulin signaling is a conserved feature in all metazoans. It evolved with the appearance of multicellularity, allowing primordial metazoans to respond to a greater diversity of environmental signals. The insulin signaling pathway is highly conserved in insects and particularly in Drosophila, where it has been extensively studied in recent years and shown to control metabolism, growth, reproduction, and longevity. Because misregulation of the insulin/IGF pathway in humans plays a role in many medical disorders, such as diabetes and various types of cancer, unraveling the regulation of insulin/IGF signaling using the power of a genetically tractable organism like Drosophila may contribute to the amelioration of these major human pathologies.
AB - Insulin signaling is a conserved feature in all metazoans. It evolved with the appearance of multicellularity, allowing primordial metazoans to respond to a greater diversity of environmental signals. The insulin signaling pathway is highly conserved in insects and particularly in Drosophila, where it has been extensively studied in recent years and shown to control metabolism, growth, reproduction, and longevity. Because misregulation of the insulin/IGF pathway in humans plays a role in many medical disorders, such as diabetes and various types of cancer, unraveling the regulation of insulin/IGF signaling using the power of a genetically tractable organism like Drosophila may contribute to the amelioration of these major human pathologies.
UR - http://www.scopus.com/inward/record.url?scp=33845543340&partnerID=8YFLogxK
U2 - 10.2337/db06-S001
DO - 10.2337/db06-S001
M3 - Journal article
AN - SCOPUS:33845543340
VL - 55
SP - S5-S8
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - SUPPL. 2
ER -
ID: 242111967