Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation
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Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation. / Linz, Dominik; Verheule, Sander; Isaacs, Aaron; Schotten, Ulrich.
In: Arrhythmia and Electrophysiology Review, Vol. 10, No. 3, 2021, p. 132-139.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation
AU - Linz, Dominik
AU - Verheule, Sander
AU - Isaacs, Aaron
AU - Schotten, Ulrich
PY - 2021
Y1 - 2021
N2 - Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.
AB - Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.
KW - Atrial fibrillation
KW - Genes
KW - Mechanisms
KW - Risk factors
KW - Substrate
UR - http://www.scopus.com/inward/record.url?scp=85118771370&partnerID=8YFLogxK
U2 - 10.15420/aer.2020.51
DO - 10.15420/aer.2020.51
M3 - Journal article
C2 - 34777816
AN - SCOPUS:85118771370
VL - 10
SP - 132
EP - 139
JO - Arrhythmia and Electrophysiology Review
JF - Arrhythmia and Electrophysiology Review
SN - 2050-3369
IS - 3
ER -
ID: 284903418