Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450
Research output: Contribution to journal › Journal article › Research › peer-review
The NADPH-dependent cytochrome P450 reductase (CPR) is a key electron donor to eucaryotic cytochromes P450 (CYPs). CPR shuttles electrons from NADPH through the FAD and FMN-coenzymes into the iron of the prosthetic heme-group of the CYP. In the course of these electron transfer reactions, CPR undergoes large conformational changes. This mini-review discusses the new evidence provided for such conformational changes involving a combination of a "swinging" and "rotating" model and highlights the molecular mechanisms by which formation of these conformations are controlled and thereby enables CPR to serve as an effective electron transferring "nano-machine".
Original language | English |
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Journal | Biochimica et Biophysica Acta - Proteins and Proteomics |
Volume | 1814 |
Issue number | 1 |
Pages (from-to) | 132-138 |
Number of pages | 7 |
ISSN | 1570-9639 |
DOIs | |
Publication status | Published - 2011 |
ID: 32167860