Compromised cardiac function in exercising teenagers with pectus excavatum
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Compromised cardiac function in exercising teenagers with pectus excavatum. / Lesbo, Maj; Tang, Mariann; Nielsen, Hans Henrik; Frøkiær, Jørgen; Lundorf, Erik; Pilegaard, Hans K; Hjortdal, Vibeke E.
In: Interactive Cardiovascular and Thoracic Surgery, Vol. 13, No. 4, 10.2011, p. 377-80.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Compromised cardiac function in exercising teenagers with pectus excavatum
AU - Lesbo, Maj
AU - Tang, Mariann
AU - Nielsen, Hans Henrik
AU - Frøkiær, Jørgen
AU - Lundorf, Erik
AU - Pilegaard, Hans K
AU - Hjortdal, Vibeke E
PY - 2011/10
Y1 - 2011/10
N2 - Patients with pectus excavatum complain about fatigue, tachypnea, discomfort and dyspnea, but the existence of an equivalent underlying pathophysiology has been questioned. We investigated 75 teenagers (49 pectus excavatum patients and 26 age matched controls) at rest and during bicycle exercise at submaximal exercise levels. At rest cardiac function was determined using echocardiography. During rest and exercise, cardiac output, heart rate and aerobic exercise capacity were measured using photo-acoustic gas-rebreathing technique for non-invasive determination of the cardiopulmonary function. At rest, no cardiac differences were found between control subjects and patients with pectus excavatum. During submaximal exercise, cardiac index was lower 6.6(6.3-7.0) l/min/m(2) among the pectus patients as compared to the control subjects 8.0(7.3-8.8) l/min/m(2), P=0.0001. The lower cardiac output among the pectus patients was due to a lower stroke index 42(39-45) ml/beat/m(2) as compared to controls 54(44-64) ml/beat/m(2), P=0.0022, whereas heart rate was unchanged. Cardiac function is significantly impaired at submaximal exercise level compared to healthy age matched controls.
AB - Patients with pectus excavatum complain about fatigue, tachypnea, discomfort and dyspnea, but the existence of an equivalent underlying pathophysiology has been questioned. We investigated 75 teenagers (49 pectus excavatum patients and 26 age matched controls) at rest and during bicycle exercise at submaximal exercise levels. At rest cardiac function was determined using echocardiography. During rest and exercise, cardiac output, heart rate and aerobic exercise capacity were measured using photo-acoustic gas-rebreathing technique for non-invasive determination of the cardiopulmonary function. At rest, no cardiac differences were found between control subjects and patients with pectus excavatum. During submaximal exercise, cardiac index was lower 6.6(6.3-7.0) l/min/m(2) among the pectus patients as compared to the control subjects 8.0(7.3-8.8) l/min/m(2), P=0.0001. The lower cardiac output among the pectus patients was due to a lower stroke index 42(39-45) ml/beat/m(2) as compared to controls 54(44-64) ml/beat/m(2), P=0.0022, whereas heart rate was unchanged. Cardiac function is significantly impaired at submaximal exercise level compared to healthy age matched controls.
KW - Adolescent
KW - Bicycling
KW - Breath Tests
KW - Cardiac Output
KW - Case-Control Studies
KW - Denmark
KW - Dyspnea/etiology
KW - Echocardiography
KW - Exercise
KW - Exercise Test
KW - Exercise Tolerance
KW - Fatigue/etiology
KW - Female
KW - Funnel Chest/complications
KW - Heart/physiopathology
KW - Heart Rate
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Respiratory Function Tests
KW - Time Factors
U2 - 10.1510/icvts.2011.267054
DO - 10.1510/icvts.2011.267054
M3 - Journal article
C2 - 21788301
VL - 13
SP - 377
EP - 380
JO - Interactive Cardiovascular and Thoracic Surgery
JF - Interactive Cardiovascular and Thoracic Surgery
SN - 1569-9293
IS - 4
ER -
ID: 242712149