Compassionate Communication and Advance Care Planning to improve End-of-life Care in Treatment of Haematological Disease 'ACT': Study Protocol for a Cluster-randomized trial
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Compassionate Communication and Advance Care Planning to improve End-of-life Care in Treatment of Haematological Disease 'ACT' : Study Protocol for a Cluster-randomized trial. / Borregaard Myrhøj, Cæcilie; Clemmensen, Stine Novrup; Jarden, Mary; Johansen, Christoffer; Von Heymann, Annika.
In: BMJ Open, Vol. 14, No. 5, e085163, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Compassionate Communication and Advance Care Planning to improve End-of-life Care in Treatment of Haematological Disease 'ACT'
T2 - Study Protocol for a Cluster-randomized trial
AU - Borregaard Myrhøj, Cæcilie
AU - Clemmensen, Stine Novrup
AU - Jarden, Mary
AU - Johansen, Christoffer
AU - Von Heymann, Annika
N1 - Publisher Copyright: © 2024 Author(s) (or their employer(s)).
PY - 2024
Y1 - 2024
N2 - Introduction To support the implementation of advance care planning and serious illness conversations in haematology, a previously developed conversation intervention titled 'Advance Consultations Concerning your Life and Treatment' (ACT) was found feasible. This study aims to investigate the effect of ACT on the quality of end-of-life care in patients with haematological malignancy and their informal caregivers. Methods and analysis The study is a nationwide 2-arm cluster randomised trial randomising 40 physician-nurse clusters across seven haematological departments in Denmark to provide standard care or ACT intervention. A total of 400 patients with haematological malignancies and their informal caregivers will be included. The ACT intervention includes an ACT conversation that centres on discussing the patient's prognosis, worries, hopes and preferences for future treatment. The intervention is supported by clinician training and supervision, preparatory materials for patients and informal caregivers, and system changes including dedicated ACT-conversation timeslots and templates for documentation in medical records. This study includes two primary outcomes: (1) the proportion of patients receiving chemotherapy within the last 30 days of death and (2) patients' and informal caregivers' symptoms of anxiety (General Anxiety Disorder-7) at 3 6, 9, 12 and 18 months follow-up. Mixed effects models accounting for clusters will be used. Ethics and dissemination The Declaration of Helsinki and the European GDPR regulations as practised in Denmark are followed through all aspects of the study. Findings will be made available to the participants, patient organisations, funding bodies, healthcare professionals and researchers at national and international conferences and through publication in peer-reviewed international journals.
AB - Introduction To support the implementation of advance care planning and serious illness conversations in haematology, a previously developed conversation intervention titled 'Advance Consultations Concerning your Life and Treatment' (ACT) was found feasible. This study aims to investigate the effect of ACT on the quality of end-of-life care in patients with haematological malignancy and their informal caregivers. Methods and analysis The study is a nationwide 2-arm cluster randomised trial randomising 40 physician-nurse clusters across seven haematological departments in Denmark to provide standard care or ACT intervention. A total of 400 patients with haematological malignancies and their informal caregivers will be included. The ACT intervention includes an ACT conversation that centres on discussing the patient's prognosis, worries, hopes and preferences for future treatment. The intervention is supported by clinician training and supervision, preparatory materials for patients and informal caregivers, and system changes including dedicated ACT-conversation timeslots and templates for documentation in medical records. This study includes two primary outcomes: (1) the proportion of patients receiving chemotherapy within the last 30 days of death and (2) patients' and informal caregivers' symptoms of anxiety (General Anxiety Disorder-7) at 3 6, 9, 12 and 18 months follow-up. Mixed effects models accounting for clusters will be used. Ethics and dissemination The Declaration of Helsinki and the European GDPR regulations as practised in Denmark are followed through all aspects of the study. Findings will be made available to the participants, patient organisations, funding bodies, healthcare professionals and researchers at national and international conferences and through publication in peer-reviewed international journals.
KW - HAEMATOLOGY
KW - PALLIATIVE CARE
KW - Psychosocial Intervention
KW - Randomized Controlled Trial
U2 - 10.1136/bmjopen-2024-085163
DO - 10.1136/bmjopen-2024-085163
M3 - Journal article
C2 - 38772898
AN - SCOPUS:85194024112
VL - 14
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 5
M1 - e085163
ER -
ID: 393597358