Comparison of EORTC QLQ-C30 and PRO-CTCAE™ Questionnaires on Six Symptom Items
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Comparison of EORTC QLQ-C30 and PRO-CTCAE™ Questionnaires on Six Symptom Items. / Taarnhøj, Gry Assam; Kennedy, Fiona R; Absolom, Kate L; Bæksted, Christina; Vogelius, Ivan R.; Johansen, Christoffer; Velikova, Galina; Pappot, Helle.
In: Journal of Pain and Symptom Management, Vol. 56, No. 3, 2018, p. 421-429.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparison of EORTC QLQ-C30 and PRO-CTCAE™ Questionnaires on Six Symptom Items
AU - Taarnhøj, Gry Assam
AU - Kennedy, Fiona R
AU - Absolom, Kate L
AU - Bæksted, Christina
AU - Vogelius, Ivan R.
AU - Johansen, Christoffer
AU - Velikova, Galina
AU - Pappot, Helle
N1 - Copyright © 2018 American Academy of Hospice and Palliative Medicine. All rights reserved.
PY - 2018
Y1 - 2018
N2 - CONTEXT: Clinical studies have over the past decade paid increasing attention to health-related quality of life data. Multiple questionnaires are often administered resulting in overlapping questions increasing patient burden.OBJECTIVES: To examine the correlations between the commonly used European Organization for Research and Treatment of Cancer Quality of Life Questionnnaire-C30 (QLQ-C30) and the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) on six coinciding items to determine consistency between overlapping items.METHODS: Data were prospectively collected from patients attending two cancer centers in the U.K. Participants completed the QLQ-C30 version 3.0 every four weeks and the PRO-CTCAE at least once a week for 12 weeks. Data were collected via the Internet or an interactive voice response. For the six coinciding items in QLQ-C30 and PRO-CTCAE: pain, nausea, vomiting, constipation, diarrhea, and fatigue, comparisons were made between all possible related responses by aligning the four responses in the QLQ-C30 with two condensed versions of the five responses in the PRO-CTCAE. Consistency and reliability was determined with the intraclass correlation coefficient (ICC) and Cronbach's α.RESULTS: About 247 patients completed 785 QLQ-C30 and 2501 PRO-CTCAE questionnaires. Moderate (ICC >0.5) to good (ICC >0.75) reliability and Cronbach's α >0.7 were found on all coinciding questions except for questions concerning the severity of nausea and vomiting as a result of relatively few patients responding to these questions. Items on frequency showed better correlations than the severity and interference items.CONCLUSION: The good reliability and consistency between the QLQ-C30 and PRO-CTCAE support future attempts to minimize patient burden by shortening health-related quality of life questionnaires.
AB - CONTEXT: Clinical studies have over the past decade paid increasing attention to health-related quality of life data. Multiple questionnaires are often administered resulting in overlapping questions increasing patient burden.OBJECTIVES: To examine the correlations between the commonly used European Organization for Research and Treatment of Cancer Quality of Life Questionnnaire-C30 (QLQ-C30) and the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) on six coinciding items to determine consistency between overlapping items.METHODS: Data were prospectively collected from patients attending two cancer centers in the U.K. Participants completed the QLQ-C30 version 3.0 every four weeks and the PRO-CTCAE at least once a week for 12 weeks. Data were collected via the Internet or an interactive voice response. For the six coinciding items in QLQ-C30 and PRO-CTCAE: pain, nausea, vomiting, constipation, diarrhea, and fatigue, comparisons were made between all possible related responses by aligning the four responses in the QLQ-C30 with two condensed versions of the five responses in the PRO-CTCAE. Consistency and reliability was determined with the intraclass correlation coefficient (ICC) and Cronbach's α.RESULTS: About 247 patients completed 785 QLQ-C30 and 2501 PRO-CTCAE questionnaires. Moderate (ICC >0.5) to good (ICC >0.75) reliability and Cronbach's α >0.7 were found on all coinciding questions except for questions concerning the severity of nausea and vomiting as a result of relatively few patients responding to these questions. Items on frequency showed better correlations than the severity and interference items.CONCLUSION: The good reliability and consistency between the QLQ-C30 and PRO-CTCAE support future attempts to minimize patient burden by shortening health-related quality of life questionnaires.
U2 - 10.1016/j.jpainsymman.2018.05.017
DO - 10.1016/j.jpainsymman.2018.05.017
M3 - Journal article
C2 - 29807157
VL - 56
SP - 421
EP - 429
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
SN - 0885-3924
IS - 3
ER -
ID: 217511112