Common genetic variants and modification of penetrance of BRCA2-associated breast cancer
Research output: Contribution to journal › Journal article › Research › peer-review
The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (
Original language | English |
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Journal | P L o S Genetics |
Volume | 6 |
Issue number | 10 |
Pages (from-to) | e1001183 |
ISSN | 1553-7390 |
DOIs | |
Publication status | Published - 1 Oct 2010 |
ID: 34120277