Standard
Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. / Mulligan, Anna Marie; Couch, Fergus J; Barrowdale, Daniel; Domchek, Susan M; Eccles, Diana; Nevanlinna, Heli; Ramus, Susan J; Robson, Mark; Sherman, Mark; Spurdle, Amanda B; Wappenschmidt, Barbara; Lee, Andrew Roger; McGuffog, Lesley; Healey, Sue; Sinilnikova, Olga M; Janavicius, Ramunas; Hansen, Thomas V O; Nielsen, Finn C; Ejlertsen, Bent; Osorio, Ana; Munoz-Repeto, Ivan; Duran, Mercedes; Godino, Javier; Pertesi, Maroulio; Benitez, Javier; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Cattaneo, Elisa; Bonanni, Bernardo; Viel, Alessandra; Pasini, Barbara; Papi, Laura; Ottini, Laura; Savarese, Antonella; Bernard, Loris; Radice, Paolo; Hamann, Ute; Verheus, Martijn; Meijers-Heijboer, Hanne Ej; Wijnen, Juul; Gomez Garcia, Encarna B; Nelen, Marcel R; Kets, C Marleen; Seynaeve, Caroline; Tilanus-Linthorst, Madeleine Ma; van der Luijt, Rob B; van Os, Theo; Rookus, Matti; Frost, Debra; Jones, J Louise; Evans, D Gareth; Lalloo, Fiona; Eeles, Ros; Izatt, Louise; Adlard, Julian; Davidson, Rosemarie; Cook, Jackie; Donaldson, Alan; Dorkins, Huw; Gregory, Helen; Eason, Jacqueline; Houghton, Catherine; Barwell, Julian; Side, Lucy E; McCann, Emma; Murray, Alex; Peock, Susan; Godwin, Andrew; Schmutzler, Rita K; Rhiem, Kerstin; Engel, Christoph; Meindl, Alfons; Ruehl, Ina; Arnold, Norbert; Niederacher, Dieter; Sutter, Christian; Deissler, Helmut; Gadzicki, Dorothea; Kast, Karin; Preisler-Adams, Sabine; Varon-Mateeva, Raymonda; Schoenbuchner, Ines; Fiebig, Britta; Heinritz, Wolfram; Schafer, Dieter; Gevensleben, Heidrun; Caux-Moncoutier, Virginie; Fassy-Colcombet, Marion; Cornelis, Francois; Mazoyer, Sylvie; Leone, Melanie; Boutry-Kryza, Nadia; Hardouin, Agnes; Berthet, Pascaline; Muller, Daniele; Fricker, Jean-Pierre; Mortemousque, Isabelle; Pujol, Pascal; Coupier, Isabelle; Lebrun, Marine; Kientz, Caroline; Longy, Michel; Sevenet, Nicolas; Stoppa-Lyonnet, Dominique; Isaacs, Claudine; Caldes, Trinidad; de Al Hoya, Miguel; Heikkinen, Tuomas; Aittomaki, Kristiina; Blanco, Ignacio; Lazaro, Conxi; Barkardottir, Rosa B; Soucy, Penny; Dumont, Martine; Simard, Jacques; Montagna, Marco; Tognazzo, Silvia; D'Andrea, Emma; Fox, Stephen; Yan, Max; Rebbeck, Timothy R; Olopade, Olufunmilayo I; Weitzel, Jeffrey N; Lynch, Henry T; Ganz, Patricia A; Tomlinson, Gail E; Wang, Xianshu; Fredericksen, Zachary; Pankratz, Vernon S; Lindor, Noralane M; Szabo, Csila; Offit, Kenneth; Sakr, Rita; Gaudet, Mia; Bhatia, Jasmine; Kauff, Noah; Singer, Christian F; Tea, Muy-Kheng; Gschwantler-Kaulich, Daphne; Fink-Retter, Anneliese; Mai, Phuong L; Greene, Mark H; Imyanitov, Evgeny; O'Malley, Frances P; Ozcelik, Hilmi; Glendon, Gordon; Toland, Amanda E; Gerdes, Anne-Marie; Thomassen, Mads; Kruse, Torben A; Birk Jensen, Uffe; Skytte, Anne-Bine; Caligo, Maria A; Soller, Maria; Henriksson, Karin; von Wachenfeldt, Anna; Arver, Brita; Stenmark-Askmalm, Marie; Karlsson, Per W.; Ding, Yuan Chun; Neuhausen, Susan L; Beattie, Mary; Pharoah, Paul Dp; Moysich, Kirsten B; Nathanson, Katherine L; Karlan, Beth Y; Gross, Jenny; John, Esther M; Daly, Mary B; Buys, Saundra M; Southey, Melissa C; Hopper, John L; Terry, Mary Beth; Chung, Wendy; Miron, Alexander F; Goldgar, David; Chenevix-Trench, Georgia; Easton, Douglas F; Andrulis, Irene L; Antoniou, Antonis C; Family Registry, Breast Cancer; Embrace; Collaborators, Gemo Study; Hebon; Network, Ontario Cancer Genetics; Swe-Brca; Cimba.
In:
Breast Cancer Research (Online Edition), Vol. 13, No. 6, 2011, p. R110.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Mulligan, AM, Couch, FJ, Barrowdale, D, Domchek, SM, Eccles, D, Nevanlinna, H, Ramus, SJ, Robson, M, Sherman, M, Spurdle, AB, Wappenschmidt, B, Lee, AR, McGuffog, L, Healey, S, Sinilnikova, OM, Janavicius, R, Hansen, TVO
, Nielsen, FC, Ejlertsen, B, Osorio, A, Munoz-Repeto, I, Duran, M, Godino, J, Pertesi, M, Benitez, J, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Cattaneo, E, Bonanni, B, Viel, A, Pasini, B, Papi, L, Ottini, L, Savarese, A, Bernard, L, Radice, P, Hamann, U, Verheus, M, Meijers-Heijboer, HE, Wijnen, J, Gomez Garcia, EB, Nelen, MR, Kets, CM, Seynaeve, C, Tilanus-Linthorst, MM, van der Luijt, RB, van Os, T, Rookus, M, Frost, D, Jones, JL, Evans, DG, Lalloo, F, Eeles, R, Izatt, L, Adlard, J, Davidson, R, Cook, J, Donaldson, A, Dorkins, H, Gregory, H, Eason, J, Houghton, C, Barwell, J, Side, LE, McCann, E, Murray, A, Peock, S, Godwin, A, Schmutzler, RK, Rhiem, K, Engel, C, Meindl, A, Ruehl, I, Arnold, N, Niederacher, D, Sutter, C, Deissler, H, Gadzicki, D, Kast, K, Preisler-Adams, S, Varon-Mateeva, R, Schoenbuchner, I, Fiebig, B, Heinritz, W, Schafer, D, Gevensleben, H, Caux-Moncoutier, V, Fassy-Colcombet, M, Cornelis, F, Mazoyer, S, Leone, M, Boutry-Kryza, N, Hardouin, A, Berthet, P, Muller, D, Fricker, J-P, Mortemousque, I, Pujol, P, Coupier, I, Lebrun, M, Kientz, C, Longy, M, Sevenet, N, Stoppa-Lyonnet, D, Isaacs, C, Caldes, T, de Al Hoya, M, Heikkinen, T, Aittomaki, K, Blanco, I, Lazaro, C, Barkardottir, RB, Soucy, P, Dumont, M, Simard, J, Montagna, M, Tognazzo, S, D'Andrea, E, Fox, S, Yan, M, Rebbeck, TR, Olopade, OI, Weitzel, JN, Lynch, HT, Ganz, PA, Tomlinson, GE, Wang, X, Fredericksen, Z, Pankratz, VS, Lindor, NM, Szabo, C, Offit, K, Sakr, R, Gaudet, M, Bhatia, J, Kauff, N, Singer, CF, Tea, M-K, Gschwantler-Kaulich, D, Fink-Retter, A, Mai, PL, Greene, MH, Imyanitov, E, O'Malley, FP, Ozcelik, H, Glendon, G, Toland, AE
, Gerdes, A-M, Thomassen, M, Kruse, TA, Birk Jensen, U, Skytte, A-B, Caligo, MA, Soller, M, Henriksson, K, von Wachenfeldt, A, Arver, B, Stenmark-Askmalm, M, Karlsson, PW, Ding, YC, Neuhausen, SL, Beattie, M, Pharoah, PD, Moysich, KB, Nathanson, KL, Karlan, BY, Gross, J, John, EM, Daly, MB, Buys, SM, Southey, MC, Hopper, JL, Terry, MB, Chung, W, Miron, AF, Goldgar, D, Chenevix-Trench, G, Easton, DF, Andrulis, IL, Antoniou, AC, Family Registry, BC, Embrace, Collaborators, GS, Hebon, Network, OCG, Swe-Brca & Cimba 2011, '
Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2',
Breast Cancer Research (Online Edition), vol. 13, no. 6, pp. R110.
https://doi.org/10.1186/bcr3052APA
Mulligan, A. M., Couch, F. J., Barrowdale, D., Domchek, S. M., Eccles, D., Nevanlinna, H., Ramus, S. J., Robson, M., Sherman, M., Spurdle, A. B., Wappenschmidt, B., Lee, A. R., McGuffog, L., Healey, S., Sinilnikova, O. M., Janavicius, R., Hansen, T. V. O.
, Nielsen, F. C., Ejlertsen, B., ... Cimba (2011).
Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.
Breast Cancer Research (Online Edition),
13(6), R110.
https://doi.org/10.1186/bcr3052Vancouver
Mulligan AM, Couch FJ, Barrowdale D, Domchek SM, Eccles D, Nevanlinna H et al.
Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.
Breast Cancer Research (Online Edition). 2011;13(6):R110.
https://doi.org/10.1186/bcr3052Author
Mulligan, Anna Marie ; Couch, Fergus J ; Barrowdale, Daniel ; Domchek, Susan M ; Eccles, Diana ; Nevanlinna, Heli ; Ramus, Susan J ; Robson, Mark ; Sherman, Mark ; Spurdle, Amanda B ; Wappenschmidt, Barbara ; Lee, Andrew Roger ; McGuffog, Lesley ; Healey, Sue ; Sinilnikova, Olga M ; Janavicius, Ramunas ; Hansen, Thomas V O ; Nielsen, Finn C ; Ejlertsen, Bent ; Osorio, Ana ; Munoz-Repeto, Ivan ; Duran, Mercedes ; Godino, Javier ; Pertesi, Maroulio ; Benitez, Javier ; Peterlongo, Paolo ; Manoukian, Siranoush ; Peissel, Bernard ; Zaffaroni, Daniela ; Cattaneo, Elisa ; Bonanni, Bernardo ; Viel, Alessandra ; Pasini, Barbara ; Papi, Laura ; Ottini, Laura ; Savarese, Antonella ; Bernard, Loris ; Radice, Paolo ; Hamann, Ute ; Verheus, Martijn ; Meijers-Heijboer, Hanne Ej ; Wijnen, Juul ; Gomez Garcia, Encarna B ; Nelen, Marcel R ; Kets, C Marleen ; Seynaeve, Caroline ; Tilanus-Linthorst, Madeleine Ma ; van der Luijt, Rob B ; van Os, Theo ; Rookus, Matti ; Frost, Debra ; Jones, J Louise ; Evans, D Gareth ; Lalloo, Fiona ; Eeles, Ros ; Izatt, Louise ; Adlard, Julian ; Davidson, Rosemarie ; Cook, Jackie ; Donaldson, Alan ; Dorkins, Huw ; Gregory, Helen ; Eason, Jacqueline ; Houghton, Catherine ; Barwell, Julian ; Side, Lucy E ; McCann, Emma ; Murray, Alex ; Peock, Susan ; Godwin, Andrew ; Schmutzler, Rita K ; Rhiem, Kerstin ; Engel, Christoph ; Meindl, Alfons ; Ruehl, Ina ; Arnold, Norbert ; Niederacher, Dieter ; Sutter, Christian ; Deissler, Helmut ; Gadzicki, Dorothea ; Kast, Karin ; Preisler-Adams, Sabine ; Varon-Mateeva, Raymonda ; Schoenbuchner, Ines ; Fiebig, Britta ; Heinritz, Wolfram ; Schafer, Dieter ; Gevensleben, Heidrun ; Caux-Moncoutier, Virginie ; Fassy-Colcombet, Marion ; Cornelis, Francois ; Mazoyer, Sylvie ; Leone, Melanie ; Boutry-Kryza, Nadia ; Hardouin, Agnes ; Berthet, Pascaline ; Muller, Daniele ; Fricker, Jean-Pierre ; Mortemousque, Isabelle ; Pujol, Pascal ; Coupier, Isabelle ; Lebrun, Marine ; Kientz, Caroline ; Longy, Michel ; Sevenet, Nicolas ; Stoppa-Lyonnet, Dominique ; Isaacs, Claudine ; Caldes, Trinidad ; de Al Hoya, Miguel ; Heikkinen, Tuomas ; Aittomaki, Kristiina ; Blanco, Ignacio ; Lazaro, Conxi ; Barkardottir, Rosa B ; Soucy, Penny ; Dumont, Martine ; Simard, Jacques ; Montagna, Marco ; Tognazzo, Silvia ; D'Andrea, Emma ; Fox, Stephen ; Yan, Max ; Rebbeck, Timothy R ; Olopade, Olufunmilayo I ; Weitzel, Jeffrey N ; Lynch, Henry T ; Ganz, Patricia A ; Tomlinson, Gail E ; Wang, Xianshu ; Fredericksen, Zachary ; Pankratz, Vernon S ; Lindor, Noralane M ; Szabo, Csila ; Offit, Kenneth ; Sakr, Rita ; Gaudet, Mia ; Bhatia, Jasmine ; Kauff, Noah ; Singer, Christian F ; Tea, Muy-Kheng ; Gschwantler-Kaulich, Daphne ; Fink-Retter, Anneliese ; Mai, Phuong L ; Greene, Mark H ; Imyanitov, Evgeny ; O'Malley, Frances P ; Ozcelik, Hilmi ; Glendon, Gordon ; Toland, Amanda E ; Gerdes, Anne-Marie ; Thomassen, Mads ; Kruse, Torben A ; Birk Jensen, Uffe ; Skytte, Anne-Bine ; Caligo, Maria A ; Soller, Maria ; Henriksson, Karin ; von Wachenfeldt, Anna ; Arver, Brita ; Stenmark-Askmalm, Marie ; Karlsson, Per W. ; Ding, Yuan Chun ; Neuhausen, Susan L ; Beattie, Mary ; Pharoah, Paul Dp ; Moysich, Kirsten B ; Nathanson, Katherine L ; Karlan, Beth Y ; Gross, Jenny ; John, Esther M ; Daly, Mary B ; Buys, Saundra M ; Southey, Melissa C ; Hopper, John L ; Terry, Mary Beth ; Chung, Wendy ; Miron, Alexander F ; Goldgar, David ; Chenevix-Trench, Georgia ; Easton, Douglas F ; Andrulis, Irene L ; Antoniou, Antonis C ; Family Registry, Breast Cancer ; Embrace ; Collaborators, Gemo Study ; Hebon ; Network, Ontario Cancer Genetics ; Swe-Brca ; Cimba. / Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. In: Breast Cancer Research (Online Edition). 2011 ; Vol. 13, No. 6. pp. R110.
Bibtex
@article{8cec1d64d1004e32910d157499e09c11,
title = "Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2",
abstract = "ABSTRACT: INTRODUCTION: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumor. METHODS: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumor, to assess the associations of twelve loci with breast cancer tumor characteristics. Associations were evaluated using a retrospective cohort approach. RESULTS: The results suggested stronger associations with ER-positive breast cancer than ER-negative for eleven loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, SNP rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele HR for ER-positive=1.35, 95%CI:1.17-1.56 vs HR=0.91, 95%CI:0.85-0.98 for ER-negative, P-heterogeneity=6.5e-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. CONCLUSIONS: The associations of the twelve SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumor subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.",
author = "Mulligan, {Anna Marie} and Couch, {Fergus J} and Daniel Barrowdale and Domchek, {Susan M} and Diana Eccles and Heli Nevanlinna and Ramus, {Susan J} and Mark Robson and Mark Sherman and Spurdle, {Amanda B} and Barbara Wappenschmidt and Lee, {Andrew Roger} and Lesley McGuffog and Sue Healey and Sinilnikova, {Olga M} and Ramunas Janavicius and Hansen, {Thomas V O} and Nielsen, {Finn C} and Bent Ejlertsen and Ana Osorio and Ivan Munoz-Repeto and Mercedes Duran and Javier Godino and Maroulio Pertesi and Javier Benitez and Paolo Peterlongo and Siranoush Manoukian and Bernard Peissel and Daniela Zaffaroni and Elisa Cattaneo and Bernardo Bonanni and Alessandra Viel and Barbara Pasini and Laura Papi and Laura Ottini and Antonella Savarese and Loris Bernard and Paolo Radice and Ute Hamann and Martijn Verheus and Meijers-Heijboer, {Hanne Ej} and Juul Wijnen and {Gomez Garcia}, {Encarna B} and Nelen, {Marcel R} and Kets, {C Marleen} and Caroline Seynaeve and Tilanus-Linthorst, {Madeleine Ma} and {van der Luijt}, {Rob B} and {van Os}, Theo and Matti Rookus and Debra Frost and Jones, {J Louise} and Evans, {D Gareth} and Fiona Lalloo and Ros Eeles and Louise Izatt and Julian Adlard and Rosemarie Davidson and Jackie Cook and Alan Donaldson and Huw Dorkins and Helen Gregory and Jacqueline Eason and Catherine Houghton and Julian Barwell and Side, {Lucy E} and Emma McCann and Alex Murray and Susan Peock and Andrew Godwin and Schmutzler, {Rita K} and Kerstin Rhiem and Christoph Engel and Alfons Meindl and Ina Ruehl and Norbert Arnold and Dieter Niederacher and Christian Sutter and Helmut Deissler and Dorothea Gadzicki and Karin Kast and Sabine Preisler-Adams and Raymonda Varon-Mateeva and Ines Schoenbuchner and Britta Fiebig and Wolfram Heinritz and Dieter Schafer and Heidrun Gevensleben and Virginie Caux-Moncoutier and Marion Fassy-Colcombet and Francois Cornelis and Sylvie Mazoyer and Melanie Leone and Nadia Boutry-Kryza and Agnes Hardouin and Pascaline Berthet and Daniele Muller and Jean-Pierre Fricker and Isabelle Mortemousque and Pascal Pujol and Isabelle Coupier and Marine Lebrun and Caroline Kientz and Michel Longy and Nicolas Sevenet and Dominique Stoppa-Lyonnet and Claudine Isaacs and Trinidad Caldes and {de Al Hoya}, Miguel and Tuomas Heikkinen and Kristiina Aittomaki and Ignacio Blanco and Conxi Lazaro and Barkardottir, {Rosa B} and Penny Soucy and Martine Dumont and Jacques Simard and Marco Montagna and Silvia Tognazzo and Emma D'Andrea and Stephen Fox and Max Yan and Rebbeck, {Timothy R} and Olopade, {Olufunmilayo I} and Weitzel, {Jeffrey N} and Lynch, {Henry T} and Ganz, {Patricia A} and Tomlinson, {Gail E} and Xianshu Wang and Zachary Fredericksen and Pankratz, {Vernon S} and Lindor, {Noralane M} and Csila Szabo and Kenneth Offit and Rita Sakr and Mia Gaudet and Jasmine Bhatia and Noah Kauff and Singer, {Christian F} and Muy-Kheng Tea and Daphne Gschwantler-Kaulich and Anneliese Fink-Retter and Mai, {Phuong L} and Greene, {Mark H} and Evgeny Imyanitov and O'Malley, {Frances P} and Hilmi Ozcelik and Gordon Glendon and Toland, {Amanda E} and Anne-Marie Gerdes and Mads Thomassen and Kruse, {Torben A} and {Birk Jensen}, Uffe and Anne-Bine Skytte and Caligo, {Maria A} and Maria Soller and Karin Henriksson and {von Wachenfeldt}, Anna and Brita Arver and Marie Stenmark-Askmalm and Karlsson, {Per W.} and Ding, {Yuan Chun} and Neuhausen, {Susan L} and Mary Beattie and Pharoah, {Paul Dp} and Moysich, {Kirsten B} and Nathanson, {Katherine L} and Karlan, {Beth Y} and Jenny Gross and John, {Esther M} and Daly, {Mary B} and Buys, {Saundra M} and Southey, {Melissa C} and Hopper, {John L} and Terry, {Mary Beth} and Wendy Chung and Miron, {Alexander F} and David Goldgar and Georgia Chenevix-Trench and Easton, {Douglas F} and Andrulis, {Irene L} and Antoniou, {Antonis C} and {Family Registry}, {Breast Cancer} and Embrace and Collaborators, {Gemo Study} and Hebon and Network, {Ontario Cancer Genetics} and Swe-Brca and Cimba",
year = "2011",
doi = "http://dx.doi.org/10.1186/bcr3052",
language = "English",
volume = "13",
pages = "R110",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "BioMed Central Ltd.",
number = "6",
}
RIS
TY - JOUR
T1 - Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
AU - Mulligan, Anna Marie
AU - Couch, Fergus J
AU - Barrowdale, Daniel
AU - Domchek, Susan M
AU - Eccles, Diana
AU - Nevanlinna, Heli
AU - Ramus, Susan J
AU - Robson, Mark
AU - Sherman, Mark
AU - Spurdle, Amanda B
AU - Wappenschmidt, Barbara
AU - Lee, Andrew Roger
AU - McGuffog, Lesley
AU - Healey, Sue
AU - Sinilnikova, Olga M
AU - Janavicius, Ramunas
AU - Hansen, Thomas V O
AU - Nielsen, Finn C
AU - Ejlertsen, Bent
AU - Osorio, Ana
AU - Munoz-Repeto, Ivan
AU - Duran, Mercedes
AU - Godino, Javier
AU - Pertesi, Maroulio
AU - Benitez, Javier
AU - Peterlongo, Paolo
AU - Manoukian, Siranoush
AU - Peissel, Bernard
AU - Zaffaroni, Daniela
AU - Cattaneo, Elisa
AU - Bonanni, Bernardo
AU - Viel, Alessandra
AU - Pasini, Barbara
AU - Papi, Laura
AU - Ottini, Laura
AU - Savarese, Antonella
AU - Bernard, Loris
AU - Radice, Paolo
AU - Hamann, Ute
AU - Verheus, Martijn
AU - Meijers-Heijboer, Hanne Ej
AU - Wijnen, Juul
AU - Gomez Garcia, Encarna B
AU - Nelen, Marcel R
AU - Kets, C Marleen
AU - Seynaeve, Caroline
AU - Tilanus-Linthorst, Madeleine Ma
AU - van der Luijt, Rob B
AU - van Os, Theo
AU - Rookus, Matti
AU - Frost, Debra
AU - Jones, J Louise
AU - Evans, D Gareth
AU - Lalloo, Fiona
AU - Eeles, Ros
AU - Izatt, Louise
AU - Adlard, Julian
AU - Davidson, Rosemarie
AU - Cook, Jackie
AU - Donaldson, Alan
AU - Dorkins, Huw
AU - Gregory, Helen
AU - Eason, Jacqueline
AU - Houghton, Catherine
AU - Barwell, Julian
AU - Side, Lucy E
AU - McCann, Emma
AU - Murray, Alex
AU - Peock, Susan
AU - Godwin, Andrew
AU - Schmutzler, Rita K
AU - Rhiem, Kerstin
AU - Engel, Christoph
AU - Meindl, Alfons
AU - Ruehl, Ina
AU - Arnold, Norbert
AU - Niederacher, Dieter
AU - Sutter, Christian
AU - Deissler, Helmut
AU - Gadzicki, Dorothea
AU - Kast, Karin
AU - Preisler-Adams, Sabine
AU - Varon-Mateeva, Raymonda
AU - Schoenbuchner, Ines
AU - Fiebig, Britta
AU - Heinritz, Wolfram
AU - Schafer, Dieter
AU - Gevensleben, Heidrun
AU - Caux-Moncoutier, Virginie
AU - Fassy-Colcombet, Marion
AU - Cornelis, Francois
AU - Mazoyer, Sylvie
AU - Leone, Melanie
AU - Boutry-Kryza, Nadia
AU - Hardouin, Agnes
AU - Berthet, Pascaline
AU - Muller, Daniele
AU - Fricker, Jean-Pierre
AU - Mortemousque, Isabelle
AU - Pujol, Pascal
AU - Coupier, Isabelle
AU - Lebrun, Marine
AU - Kientz, Caroline
AU - Longy, Michel
AU - Sevenet, Nicolas
AU - Stoppa-Lyonnet, Dominique
AU - Isaacs, Claudine
AU - Caldes, Trinidad
AU - de Al Hoya, Miguel
AU - Heikkinen, Tuomas
AU - Aittomaki, Kristiina
AU - Blanco, Ignacio
AU - Lazaro, Conxi
AU - Barkardottir, Rosa B
AU - Soucy, Penny
AU - Dumont, Martine
AU - Simard, Jacques
AU - Montagna, Marco
AU - Tognazzo, Silvia
AU - D'Andrea, Emma
AU - Fox, Stephen
AU - Yan, Max
AU - Rebbeck, Timothy R
AU - Olopade, Olufunmilayo I
AU - Weitzel, Jeffrey N
AU - Lynch, Henry T
AU - Ganz, Patricia A
AU - Tomlinson, Gail E
AU - Wang, Xianshu
AU - Fredericksen, Zachary
AU - Pankratz, Vernon S
AU - Lindor, Noralane M
AU - Szabo, Csila
AU - Offit, Kenneth
AU - Sakr, Rita
AU - Gaudet, Mia
AU - Bhatia, Jasmine
AU - Kauff, Noah
AU - Singer, Christian F
AU - Tea, Muy-Kheng
AU - Gschwantler-Kaulich, Daphne
AU - Fink-Retter, Anneliese
AU - Mai, Phuong L
AU - Greene, Mark H
AU - Imyanitov, Evgeny
AU - O'Malley, Frances P
AU - Ozcelik, Hilmi
AU - Glendon, Gordon
AU - Toland, Amanda E
AU - Gerdes, Anne-Marie
AU - Thomassen, Mads
AU - Kruse, Torben A
AU - Birk Jensen, Uffe
AU - Skytte, Anne-Bine
AU - Caligo, Maria A
AU - Soller, Maria
AU - Henriksson, Karin
AU - von Wachenfeldt, Anna
AU - Arver, Brita
AU - Stenmark-Askmalm, Marie
AU - Karlsson, Per W.
AU - Ding, Yuan Chun
AU - Neuhausen, Susan L
AU - Beattie, Mary
AU - Pharoah, Paul Dp
AU - Moysich, Kirsten B
AU - Nathanson, Katherine L
AU - Karlan, Beth Y
AU - Gross, Jenny
AU - John, Esther M
AU - Daly, Mary B
AU - Buys, Saundra M
AU - Southey, Melissa C
AU - Hopper, John L
AU - Terry, Mary Beth
AU - Chung, Wendy
AU - Miron, Alexander F
AU - Goldgar, David
AU - Chenevix-Trench, Georgia
AU - Easton, Douglas F
AU - Andrulis, Irene L
AU - Antoniou, Antonis C
AU - Family Registry, Breast Cancer
AU - Embrace, null
AU - Collaborators, Gemo Study
AU - Hebon, null
AU - Network, Ontario Cancer Genetics
AU - Swe-Brca, null
AU - Cimba, null
PY - 2011
Y1 - 2011
N2 - ABSTRACT: INTRODUCTION: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumor. METHODS: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumor, to assess the associations of twelve loci with breast cancer tumor characteristics. Associations were evaluated using a retrospective cohort approach. RESULTS: The results suggested stronger associations with ER-positive breast cancer than ER-negative for eleven loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, SNP rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele HR for ER-positive=1.35, 95%CI:1.17-1.56 vs HR=0.91, 95%CI:0.85-0.98 for ER-negative, P-heterogeneity=6.5e-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. CONCLUSIONS: The associations of the twelve SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumor subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.
AB - ABSTRACT: INTRODUCTION: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumor. METHODS: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumor, to assess the associations of twelve loci with breast cancer tumor characteristics. Associations were evaluated using a retrospective cohort approach. RESULTS: The results suggested stronger associations with ER-positive breast cancer than ER-negative for eleven loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, SNP rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele HR for ER-positive=1.35, 95%CI:1.17-1.56 vs HR=0.91, 95%CI:0.85-0.98 for ER-negative, P-heterogeneity=6.5e-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. CONCLUSIONS: The associations of the twelve SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumor subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.
U2 - http://dx.doi.org/10.1186/bcr3052
DO - http://dx.doi.org/10.1186/bcr3052
M3 - Journal article
VL - 13
SP - R110
JO - Breast Cancer Research
JF - Breast Cancer Research
SN - 1465-5411
IS - 6
ER -
