Collagen biology and non-invasive biomarkers of liver fibrosis
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Collagen biology and non-invasive biomarkers of liver fibrosis. / Karsdal, Morten A.; Daniels, Samuel J.; Holm Nielsen, Signe; Bager, Cecilie; Rasmussen, Daniel G.K.; Loomba, Rohit; Surabattula, Rambabu; Villesen, Ida Falk; Luo, Yi; Shevell, Diane; Gudmann, Natasja S.; Nielsen, Mette J.; George, Jacob; Christian, Rose; Leeming, Diana J.; Schuppan, Detlef.
In: Liver International, Vol. 40, No. 4, 2020, p. 736-750.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Collagen biology and non-invasive biomarkers of liver fibrosis
AU - Karsdal, Morten A.
AU - Daniels, Samuel J.
AU - Holm Nielsen, Signe
AU - Bager, Cecilie
AU - Rasmussen, Daniel G.K.
AU - Loomba, Rohit
AU - Surabattula, Rambabu
AU - Villesen, Ida Falk
AU - Luo, Yi
AU - Shevell, Diane
AU - Gudmann, Natasja S.
AU - Nielsen, Mette J.
AU - George, Jacob
AU - Christian, Rose
AU - Leeming, Diana J.
AU - Schuppan, Detlef
N1 - Publisher Copyright: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2020
Y1 - 2020
N2 - There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.
AB - There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.
KW - biomarker
KW - cirrhosis
KW - collagen
KW - fibrogenesis
KW - fibrolysis
KW - fibrosis
KW - HBV
KW - HCV
KW - liver
KW - monitoring
KW - NAFLD
KW - NASH
KW - non-invasive
KW - peptide
KW - plasma
KW - procollagen
KW - serum
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85079714960&partnerID=8YFLogxK
U2 - 10.1111/liv.14390
DO - 10.1111/liv.14390
M3 - Review
C2 - 31997561
AN - SCOPUS:85079714960
VL - 40
SP - 736
EP - 750
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - 4
ER -
ID: 270628556