Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
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Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. / U-Din, Mueez; de Mello, Vanessa D.; Tuomainen, Marjo; Raiko, Juho; Niemi, Tarja; Fromme, Tobias; Klåvus, Anton; Gautier, Nadine; Haimilahti, Kimmo; Lehtonen, Marko; Kristiansen, Karsten; Newman, John W.; Pietiläinen, Kirsi H.; Pihlajamäki, Jussi; Amri, Ez Zoubir; Klingenspor, Martin; Nuutila, Pirjo; Pirinen, Eija; Hanhineva, Kati; Virtanen, Kirsi A.
In: Cell Reports, Vol. 42, No. 9, 113131, 26.09.2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
AU - U-Din, Mueez
AU - de Mello, Vanessa D.
AU - Tuomainen, Marjo
AU - Raiko, Juho
AU - Niemi, Tarja
AU - Fromme, Tobias
AU - Klåvus, Anton
AU - Gautier, Nadine
AU - Haimilahti, Kimmo
AU - Lehtonen, Marko
AU - Kristiansen, Karsten
AU - Newman, John W.
AU - Pietiläinen, Kirsi H.
AU - Pihlajamäki, Jussi
AU - Amri, Ez Zoubir
AU - Klingenspor, Martin
AU - Nuutila, Pirjo
AU - Pirinen, Eija
AU - Hanhineva, Kati
AU - Virtanen, Kirsi A.
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023/9/26
Y1 - 2023/9/26
N2 - Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.
AB - Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.
KW - BAT
KW - cold exposure
KW - CP: Metabolism
KW - human brown adipose tissue
KW - NAD
KW - nicotinamide
KW - tryptophan
U2 - 10.1016/j.celrep.2023.113131
DO - 10.1016/j.celrep.2023.113131
M3 - Journal article
C2 - 37708023
AN - SCOPUS:85171357961
VL - 42
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 9
M1 - 113131
ER -
ID: 367905499