Circulating nitric oxide products do not solely reflect nitric oxide release in cirrhosis and portal hypertension
Research output: Contribution to journal › Journal article › Research › peer-review
Patients with cirrhosis often develop a systemic vasodilatation and a hyperdynamic circulation with activation of vasoconstrictor systems such as the renin-angiotensin-aldosterone system (RAAS), and vasopressin. Increased nitric oxide (NO) synthesis has been implicated in the development of this state of vasodilation and pulmonary dysfunction including increased exhaled NO concentrations. Circulating metabolites (NO(x)) may affect the systemic and pulmonary NO-generation. However, the relations of these abnormalities to the haemodynamic changes remain unclear.
Original language | English |
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Journal | Liver International |
Volume | 31 |
Issue number | 9 |
Pages (from-to) | 1381-7 |
Number of pages | 7 |
ISSN | 1478-3223 |
DOIs | |
Publication status | Published - Oct 2011 |
ID: 40142968