Circulating metabolites associated with postprandial satiety in overweight/obese participants: The SATIN Study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Circulating metabolites associated with postprandial satiety in overweight/obese participants: The SATIN Study. / Camacho-Barcia, Lucía; García-Gavilán, Jesús; Papandreou, Christopher; Hansen, Thea Toft; Harrold, Jo A.; Finlayson, Graham; Blundell, John E; Sjödin, Anders; Halford, Jason C G; Bulló, Mònica.
In: Nutrients, Vol. 13, No. 2, 549, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Circulating metabolites associated with postprandial satiety in overweight/obese participants: The SATIN Study
AU - Camacho-Barcia, Lucía
AU - García-Gavilán, Jesús
AU - Papandreou, Christopher
AU - Hansen, Thea Toft
AU - Harrold, Jo A.
AU - Finlayson, Graham
AU - Blundell, John E
AU - Sjödin, Anders
AU - Halford, Jason C G
AU - Bulló, Mònica
N1 - CURIS 2021 NEXS 087
PY - 2021
Y1 - 2021
N2 - Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the “Satiety Innovation”-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson’s correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively.Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects.
AB - Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the “Satiety Innovation”-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson’s correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively.Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects.
KW - Metabolomics
KW - Obesity
KW - Satiety
UR - http://www.scopus.com/inward/record.url?scp=85100535968&partnerID=8YFLogxK
U2 - 10.3390/nu13020549
DO - 10.3390/nu13020549
M3 - Journal article
C2 - 33567505
AN - SCOPUS:85100535968
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 549
ER -
ID: 257742771