TY - JOUR

T1 - Chromium – a scoping review for Nordic Nutrition Recommendations 2023

AU - Henriksen, Christine

AU - Bügel, Susanne

N1 - Publisher Copyright: © 2023 Christine Henriksen and Susanne Büge.

PY - 2023

Y1 - 2023

N2 - Trivalent chromium (CrIII) is the principal form of chromium found in diet and supplements. CrIII has been claimed to be involved in the regulation of carbohydrate, lipid, and protein metabolism. Hexavalent chromium (CrVI) is a carcinogen when inhaled, which is uncommon, and occurs mainly by occupational exposures. There is a concern about adverse health effects also from exposure to CrVI by contaminated drinking water, although data from human studies are limited. Chromium had no recommendation in the Nordic Nutrition Recommendations (NNR) 2012 and the European Food Safety Authority (EFSA) did not set any reference values either. Methods for evaluating chromium status are lacking, and there is still uncertainty about how chromium deficiency in humans manifests itself. The essentiality of chromium is also disputed. This scoping review revealed new research activity relating to high-dose chromium supplements and several health outcomes (overweight, obesity, and diabetes). Although these issues are related to health concerns in the Nordic or Baltic countries, the relevance for the NNR is modest, since such a high intake of chromium cannot be achieved by diet. Thus, no strong evidence was identified in the scientific literature that justifies a recommendation for chromium intake.

AB - Trivalent chromium (CrIII) is the principal form of chromium found in diet and supplements. CrIII has been claimed to be involved in the regulation of carbohydrate, lipid, and protein metabolism. Hexavalent chromium (CrVI) is a carcinogen when inhaled, which is uncommon, and occurs mainly by occupational exposures. There is a concern about adverse health effects also from exposure to CrVI by contaminated drinking water, although data from human studies are limited. Chromium had no recommendation in the Nordic Nutrition Recommendations (NNR) 2012 and the European Food Safety Authority (EFSA) did not set any reference values either. Methods for evaluating chromium status are lacking, and there is still uncertainty about how chromium deficiency in humans manifests itself. The essentiality of chromium is also disputed. This scoping review revealed new research activity relating to high-dose chromium supplements and several health outcomes (overweight, obesity, and diabetes). Although these issues are related to health concerns in the Nordic or Baltic countries, the relevance for the NNR is modest, since such a high intake of chromium cannot be achieved by diet. Thus, no strong evidence was identified in the scientific literature that justifies a recommendation for chromium intake.

KW - nutrition recommendations

KW - toxicity

KW - trace elements

U2 - 10.29219/fnr.v67.10325

DO - 10.29219/fnr.v67.10325

M3 - Review

C2 - 38084146

AN - SCOPUS:85178951273

VL - 67

JO - Scandinavian Journal of Nutrition/Naringsforskning, Supplement

JF - Scandinavian Journal of Nutrition/Naringsforskning, Supplement

SN - 1102-6510

M1 - 10325

ER -