TY - JOUR

T1 - Changes in alcohol intake and risk of upper digestive tract cancer

AU - Thygesen, Lau C

AU - Keiding, Niels

AU - Johansen, Christoffer

AU - Grønbaek, Morten

N1 - Keywords: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Body Mass Index; Carcinoma; Cohort Studies; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Socioeconomic Factors; Upper Gastrointestinal Tract

PY - 2007

Y1 - 2007

N2 - INTRODUCTION: Alcohol intake measured at one point in time is a strong predictor for later development of cancer of the oral cavity, pharynx, larynx and esophagus. In this prospective cohort study, we examined whether changes in individual alcohol intake resulted in subsequent altered risk of these cancers. MATERIAL AND METHODS: In the Copenhagen City Heart Study we assessed alcohol intake among 4 896 men and 6 239 women who participated at both the first (1976-1978) and second (1981-1983) examination of the study. Alcohol intake changes on risk of upper digestive tract cancer 1981-2002 were examined by a Cox model adjusted for potential confounders. RESULTS: Despite a small number of cases (n = 105), alcohol intake increase > 14 drinks/week was associated with significantly elevated risk (hazard ratio = 2.5; 95% confidence interval, 1.1-5.3), while suggestively decreased risk was observed for persons lowering alcohol intake > 7 drinks/week (0.5; 0.1-2.5). The trend test was highly significant (p < 0.0001). CONCLUSIONS: These findings support public health messages of not increasing alcohol intake and lowering consumption among people with high alcohol intake.

AB - INTRODUCTION: Alcohol intake measured at one point in time is a strong predictor for later development of cancer of the oral cavity, pharynx, larynx and esophagus. In this prospective cohort study, we examined whether changes in individual alcohol intake resulted in subsequent altered risk of these cancers. MATERIAL AND METHODS: In the Copenhagen City Heart Study we assessed alcohol intake among 4 896 men and 6 239 women who participated at both the first (1976-1978) and second (1981-1983) examination of the study. Alcohol intake changes on risk of upper digestive tract cancer 1981-2002 were examined by a Cox model adjusted for potential confounders. RESULTS: Despite a small number of cases (n = 105), alcohol intake increase > 14 drinks/week was associated with significantly elevated risk (hazard ratio = 2.5; 95% confidence interval, 1.1-5.3), while suggestively decreased risk was observed for persons lowering alcohol intake > 7 drinks/week (0.5; 0.1-2.5). The trend test was highly significant (p < 0.0001). CONCLUSIONS: These findings support public health messages of not increasing alcohol intake and lowering consumption among people with high alcohol intake.

U2 - 10.1080/02841860701441806

DO - 10.1080/02841860701441806

M3 - Journal article

C2 - 17851863

VL - 46

SP - 1085

EP - 1089

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1100-1704

IS - 8

ER -