Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans
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Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans. / Berg, Ronan Mg; Taudorf, Sarah; Bailey, Damian M; Lundby, Carsten; Larsen, Fin Stolze; Pedersen, Bente Klarlund; Møller, Kirsten; Møller, Kirsten.
In: Critical Care, Vol. 14, No. 1, 01.01.2010, p. R16.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans
AU - Berg, Ronan Mg
AU - Taudorf, Sarah
AU - Bailey, Damian M
AU - Lundby, Carsten
AU - Larsen, Fin Stolze
AU - Pedersen, Bente Klarlund
AU - Møller, Kirsten
AU - Møller, Kirsten
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.
AB - Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.
U2 - 10.1186/cc8873
DO - 10.1186/cc8873
M3 - Journal article
VL - 14
SP - R16
JO - Critical Care
JF - Critical Care
SN - 1364-8535
IS - 1
ER -
ID: 34113389