Cerebral blood flow in untreated and treated hypertension

Research output: Contribution to journal › Review › Research › peer-review

Standard

Cerebral blood flow in untreated and treated hypertension. / Strandgaard, S; Paulson, O B.

In: Netherlands Journal of Medicine, Vol. 47, No. 4, 10.1995, p. 180-4.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Strandgaard, S & Paulson, OB 1995, 'Cerebral blood flow in untreated and treated hypertension', Netherlands Journal of Medicine, vol. 47, no. 4, pp. 180-4. https://doi.org/10.1016/0300-2977(95)00065-u

APA

Strandgaard, S., & Paulson, O. B. (1995). Cerebral blood flow in untreated and treated hypertension. Netherlands Journal of Medicine, 47(4), 180-4. https://doi.org/10.1016/0300-2977(95)00065-u

Vancouver

Strandgaard S, Paulson OB. Cerebral blood flow in untreated and treated hypertension. Netherlands Journal of Medicine. 1995 Oct;47(4):180-4. https://doi.org/10.1016/0300-2977(95)00065-u

Author

Strandgaard, S ; Paulson, O B. / Cerebral blood flow in untreated and treated hypertension. In: Netherlands Journal of Medicine. 1995 ; Vol. 47, No. 4. pp. 180-4.

Bibtex

@article{e93d7a6af042417fb45de675f7298f0a,
title = "Cerebral blood flow in untreated and treated hypertension",
abstract = "Cerebral blood flow (CBF) is the same in hypertensive and normotensive man without neurological deficit. Chronic hypertension shifts the lower and upper blood pressure limits of CBF autoregulation towards higher pressure. Acute blood pressure reduction will lower CBF only if the pressure is taken below the lower limit of autoregulation. Added to this, some drugs are cerebral vasodilatators and have the potential for paralysing autoregulation and raising intracranial pressure, an effect also seen with at least some calcium antagonists. Converting enzyme inhibitors improve autoregulation during hypotension, probably by releasing angiotensin II dependent tone in the larger cerebral resistance vessels. With chronic antihypertensive treatment, CBF autoregulation may re-adapt towards normal. Converting enzyme inhibitors when given chronically probably retain their beneficial effect on the lower limit of autoregulation. Apart from this, it is uncertain whether there are chronic pharmacological effects of antihypertensive drugs directly on the cerebral circulation.",
keywords = "Antihypertensive Agents/therapeutic use, Cerebrovascular Circulation/drug effects, Homeostasis, Humans, Hypertension/drug therapy, Male",
author = "S Strandgaard and Paulson, {O B}",
year = "1995",
month = oct,
doi = "10.1016/0300-2977(95)00065-u",
language = "English",
volume = "47",
pages = "180--4",
journal = "Netherlands Journal of Medicine",
issn = "0300-2977",
publisher = "Van Zuiden Communications B.V.",
number = "4",

}

RIS

TY - JOUR

T1 - Cerebral blood flow in untreated and treated hypertension

AU - Strandgaard, S

AU - Paulson, O B

PY - 1995/10

Y1 - 1995/10

N2 - Cerebral blood flow (CBF) is the same in hypertensive and normotensive man without neurological deficit. Chronic hypertension shifts the lower and upper blood pressure limits of CBF autoregulation towards higher pressure. Acute blood pressure reduction will lower CBF only if the pressure is taken below the lower limit of autoregulation. Added to this, some drugs are cerebral vasodilatators and have the potential for paralysing autoregulation and raising intracranial pressure, an effect also seen with at least some calcium antagonists. Converting enzyme inhibitors improve autoregulation during hypotension, probably by releasing angiotensin II dependent tone in the larger cerebral resistance vessels. With chronic antihypertensive treatment, CBF autoregulation may re-adapt towards normal. Converting enzyme inhibitors when given chronically probably retain their beneficial effect on the lower limit of autoregulation. Apart from this, it is uncertain whether there are chronic pharmacological effects of antihypertensive drugs directly on the cerebral circulation.

AB - Cerebral blood flow (CBF) is the same in hypertensive and normotensive man without neurological deficit. Chronic hypertension shifts the lower and upper blood pressure limits of CBF autoregulation towards higher pressure. Acute blood pressure reduction will lower CBF only if the pressure is taken below the lower limit of autoregulation. Added to this, some drugs are cerebral vasodilatators and have the potential for paralysing autoregulation and raising intracranial pressure, an effect also seen with at least some calcium antagonists. Converting enzyme inhibitors improve autoregulation during hypotension, probably by releasing angiotensin II dependent tone in the larger cerebral resistance vessels. With chronic antihypertensive treatment, CBF autoregulation may re-adapt towards normal. Converting enzyme inhibitors when given chronically probably retain their beneficial effect on the lower limit of autoregulation. Apart from this, it is uncertain whether there are chronic pharmacological effects of antihypertensive drugs directly on the cerebral circulation.

KW - Antihypertensive Agents/therapeutic use

KW - Cerebrovascular Circulation/drug effects

KW - Homeostasis

KW - Humans

KW - Hypertension/drug therapy

KW - Male

U2 - 10.1016/0300-2977(95)00065-u

DO - 10.1016/0300-2977(95)00065-u

M3 - Review

C2 - 8538822

VL - 47

SP - 180

EP - 184

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

SN - 0300-2977

IS - 4

ER -

ID: 279848160