Biglycan deficiency interferes with ovariectomy-induced bone loss
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Biglycan deficiency interferes with ovariectomy-induced bone loss. / Nielsen, Karina L; Allen, Matthew R; Bloomfield, Susan A; Andersen, Thomas L; Chen, Xiao-Dong; Poulsen, Hans S; Young, Marian F; Heegaard, Anne-Marie.
In: Journal of Bone and Mineral Research, Vol. 18, No. 12, 2003, p. 2152-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Biglycan deficiency interferes with ovariectomy-induced bone loss
AU - Nielsen, Karina L
AU - Allen, Matthew R
AU - Bloomfield, Susan A
AU - Andersen, Thomas L
AU - Chen, Xiao-Dong
AU - Poulsen, Hans S
AU - Young, Marian F
AU - Heegaard, Anne-Marie
PY - 2003
Y1 - 2003
N2 - Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.
AB - Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.
KW - Animals
KW - Biglycan
KW - Bone Density
KW - Carrier Proteins
KW - Extracellular Matrix Proteins
KW - Female
KW - Glycoproteins
KW - Male
KW - Membrane Glycoproteins
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Models, Animal
KW - Osteoclasts
KW - Osteoporosis
KW - Osteoprotegerin
KW - Ovariectomy
KW - Proteoglycans
KW - RANK Ligand
KW - Receptor Activator of Nuclear Factor-kappa B
KW - Receptors, Cytoplasmic and Nuclear
KW - Receptors, Tumor Necrosis Factor
U2 - 10.1359/jbmr.2003.18.12.2152
DO - 10.1359/jbmr.2003.18.12.2152
M3 - Journal article
C2 - 14672350
VL - 18
SP - 2152
EP - 2158
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 12
ER -
ID: 38426449