Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
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Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. / Brakebusch, Cord; Fillatreau, Simon; Potocnik, Alexandre J; Bungartz, Gerd; Wilhelm, Patricia; Svensson, Marcus; Kearney, Phil; Körner, Heinrich; Gray, David; Fässler, Reinhard.
In: Immunity, Vol. 16, No. 3, 2002, p. 465-77.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
AU - Brakebusch, Cord
AU - Fillatreau, Simon
AU - Potocnik, Alexandre J
AU - Bungartz, Gerd
AU - Wilhelm, Patricia
AU - Svensson, Marcus
AU - Kearney, Phil
AU - Körner, Heinrich
AU - Gray, David
AU - Fässler, Reinhard
N1 - Keywords: Animals; Antibody Formation; Antigens, CD29; B-Lymphocytes; Gene Deletion; Gene Expression Regulation; Hematopoiesis; Immunoglobulin M; Mice; T-Lymphocytes
PY - 2002
Y1 - 2002
N2 - Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.
AB - Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.
M3 - Journal article
C2 - 11911830
VL - 16
SP - 465
EP - 477
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 3
ER -
ID: 5141566