Behavioral encoding across timescales by region-specific dopamine dynamics
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Behavioral encoding across timescales by region-specific dopamine dynamics. / Jørgensen, Søren H.; Ejdrup, Aske L.; Lycas, Matthew D.; Posselt, Leonie P.; Madsen, Kenneth L.; Tian, Lin; Dreyer, Jakob K.; Herborg, Freja; Sørensen, Andreas T.; Gether, Ulrik.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, No. 7, e2215230120, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Behavioral encoding across timescales by region-specific dopamine dynamics
AU - Jørgensen, Søren H.
AU - Ejdrup, Aske L.
AU - Lycas, Matthew D.
AU - Posselt, Leonie P.
AU - Madsen, Kenneth L.
AU - Tian, Lin
AU - Dreyer, Jakob K.
AU - Herborg, Freja
AU - Sørensen, Andreas T.
AU - Gether, Ulrik
PY - 2023
Y1 - 2023
N2 - The dorsal (DS) and ventral striatum (VS) receive dopaminergic projections that control motor functions and reward-related behavior. It remains poorly understood how dopamine release dynamics across different temporal scales in these regions are coupled to behavioral outcomes. Here, we employ the dopamine sensor dLight1.3b together with multiregion fiber photometry and machine learning-based analysis to decode dopamine dynamics across the striatum during self-paced exploratory behavior in mice. Our data show a striking coordination of rapidly fluctuating signal in the DS, carrying information across dopamine levels, with a slower signal in the VS, consisting mainly of slow-paced transients. Importantly, these release dynamics correlated with discrete behavioral motifs, such as turns, running, and grooming on a subsecond-to-minute time scale. Disruption of dopamine dynamics with cocaine caused randomization of action selection sequencing and disturbance of DS-VS coordination. The data suggest that distinct dopamine dynamics of DS and VS jointly encode behavioral sequences during unconstrained activity with DS modulating the stringing together of actions and VS the signal to initiate and sustain the selected action.
AB - The dorsal (DS) and ventral striatum (VS) receive dopaminergic projections that control motor functions and reward-related behavior. It remains poorly understood how dopamine release dynamics across different temporal scales in these regions are coupled to behavioral outcomes. Here, we employ the dopamine sensor dLight1.3b together with multiregion fiber photometry and machine learning-based analysis to decode dopamine dynamics across the striatum during self-paced exploratory behavior in mice. Our data show a striking coordination of rapidly fluctuating signal in the DS, carrying information across dopamine levels, with a slower signal in the VS, consisting mainly of slow-paced transients. Importantly, these release dynamics correlated with discrete behavioral motifs, such as turns, running, and grooming on a subsecond-to-minute time scale. Disruption of dopamine dynamics with cocaine caused randomization of action selection sequencing and disturbance of DS-VS coordination. The data suggest that distinct dopamine dynamics of DS and VS jointly encode behavioral sequences during unconstrained activity with DS modulating the stringing together of actions and VS the signal to initiate and sustain the selected action.
KW - cocaine
KW - dopamine release
KW - dopamine sensors
KW - machine learning
KW - mouse behavior
U2 - 10.1073/pnas.2215230120
DO - 10.1073/pnas.2215230120
M3 - Journal article
C2 - 36749722
AN - SCOPUS:85147720901
VL - 120
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 7
M1 - e2215230120
ER -
ID: 336255713