BCG Vaccination and Risk of Atopy

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BCG Vaccination and Risk of Atopy. / Krause, Tyra G.; Hviid, Anders; Koch, Anders; Friborg, Jeppe; Hjuler, Thomas; Wohlfahrt, Jan; Olsen, Ove Rosing; Kristensen, Bjarne; Melbye, Mads.

In: Journal of the American Medical Association, Vol. 289, No. 8, 26.02.2003, p. 1012-1015.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Krause, TG, Hviid, A, Koch, A, Friborg, J, Hjuler, T, Wohlfahrt, J, Olsen, OR, Kristensen, B & Melbye, M 2003, 'BCG Vaccination and Risk of Atopy', Journal of the American Medical Association, vol. 289, no. 8, pp. 1012-1015. https://doi.org/10.1001/jama.289.8.1012

APA

Krause, T. G., Hviid, A., Koch, A., Friborg, J., Hjuler, T., Wohlfahrt, J., Olsen, O. R., Kristensen, B., & Melbye, M. (2003). BCG Vaccination and Risk of Atopy. Journal of the American Medical Association, 289(8), 1012-1015. https://doi.org/10.1001/jama.289.8.1012

Vancouver

Krause TG, Hviid A, Koch A, Friborg J, Hjuler T, Wohlfahrt J et al. BCG Vaccination and Risk of Atopy. Journal of the American Medical Association. 2003 Feb 26;289(8):1012-1015. https://doi.org/10.1001/jama.289.8.1012

Author

Krause, Tyra G. ; Hviid, Anders ; Koch, Anders ; Friborg, Jeppe ; Hjuler, Thomas ; Wohlfahrt, Jan ; Olsen, Ove Rosing ; Kristensen, Bjarne ; Melbye, Mads. / BCG Vaccination and Risk of Atopy. In: Journal of the American Medical Association. 2003 ; Vol. 289, No. 8. pp. 1012-1015.

Bibtex

@article{b46f9e02484b4c568526e2e54acfbfce,
title = "BCG Vaccination and Risk of Atopy",
abstract = "Context: It has been suggested that BCG vaccination may protect against development of allergic diseases, particularly when given just after birth. BCG vaccination was given routinely to all infants in Greenland until 1990, when it was withdrawn from the vaccination program. Whether this resulted in an increased prevalence of atopy in children born after the stop of BCG vaccination is unknown. Objective: To determine whether BCG vaccination and age at BCG vaccination are associated with development of atopy. Design, Setting, and Participants: Cross-sectional study among schoolchildren aged 8 to 16 years in 4 towns on the northwest coast of Greenland. Participants had a blood sample drawn and information on BCG vaccination was obtained during 2 periods, November 1998 and November 2001. A total of 1686 children (79% of available children) participated, 1575 of whom had complete information on vaccination status. Atopy was defined as a positive test result in an assay that tests for IgE specific against the most common inhalant allergens in serum. Main Outcome Measures: Odds ratio (OR) of atopy in BCG-vaccinated compared with unvaccinated children and OR according to age at vaccination. Results: The risk of atopy was the same in BCG-vaccinated compared with unvaccinated children after adjustment for confounders (OR, 1.03; 95% confidence interval, 0.72-1.48). The risk of atopy in BCG-vaccinated children was not associated with age at vaccination (P = .17). Conclusions: BCG vaccination administered to infants is not associated with reduced risk of development of atopy.",
author = "Krause, {Tyra G.} and Anders Hviid and Anders Koch and Jeppe Friborg and Thomas Hjuler and Jan Wohlfahrt and Olsen, {Ove Rosing} and Bjarne Kristensen and Mads Melbye",
year = "2003",
month = feb,
day = "26",
doi = "10.1001/jama.289.8.1012",
language = "English",
volume = "289",
pages = "1012--1015",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "8",

}

RIS

TY - JOUR

T1 - BCG Vaccination and Risk of Atopy

AU - Krause, Tyra G.

AU - Hviid, Anders

AU - Koch, Anders

AU - Friborg, Jeppe

AU - Hjuler, Thomas

AU - Wohlfahrt, Jan

AU - Olsen, Ove Rosing

AU - Kristensen, Bjarne

AU - Melbye, Mads

PY - 2003/2/26

Y1 - 2003/2/26

N2 - Context: It has been suggested that BCG vaccination may protect against development of allergic diseases, particularly when given just after birth. BCG vaccination was given routinely to all infants in Greenland until 1990, when it was withdrawn from the vaccination program. Whether this resulted in an increased prevalence of atopy in children born after the stop of BCG vaccination is unknown. Objective: To determine whether BCG vaccination and age at BCG vaccination are associated with development of atopy. Design, Setting, and Participants: Cross-sectional study among schoolchildren aged 8 to 16 years in 4 towns on the northwest coast of Greenland. Participants had a blood sample drawn and information on BCG vaccination was obtained during 2 periods, November 1998 and November 2001. A total of 1686 children (79% of available children) participated, 1575 of whom had complete information on vaccination status. Atopy was defined as a positive test result in an assay that tests for IgE specific against the most common inhalant allergens in serum. Main Outcome Measures: Odds ratio (OR) of atopy in BCG-vaccinated compared with unvaccinated children and OR according to age at vaccination. Results: The risk of atopy was the same in BCG-vaccinated compared with unvaccinated children after adjustment for confounders (OR, 1.03; 95% confidence interval, 0.72-1.48). The risk of atopy in BCG-vaccinated children was not associated with age at vaccination (P = .17). Conclusions: BCG vaccination administered to infants is not associated with reduced risk of development of atopy.

AB - Context: It has been suggested that BCG vaccination may protect against development of allergic diseases, particularly when given just after birth. BCG vaccination was given routinely to all infants in Greenland until 1990, when it was withdrawn from the vaccination program. Whether this resulted in an increased prevalence of atopy in children born after the stop of BCG vaccination is unknown. Objective: To determine whether BCG vaccination and age at BCG vaccination are associated with development of atopy. Design, Setting, and Participants: Cross-sectional study among schoolchildren aged 8 to 16 years in 4 towns on the northwest coast of Greenland. Participants had a blood sample drawn and information on BCG vaccination was obtained during 2 periods, November 1998 and November 2001. A total of 1686 children (79% of available children) participated, 1575 of whom had complete information on vaccination status. Atopy was defined as a positive test result in an assay that tests for IgE specific against the most common inhalant allergens in serum. Main Outcome Measures: Odds ratio (OR) of atopy in BCG-vaccinated compared with unvaccinated children and OR according to age at vaccination. Results: The risk of atopy was the same in BCG-vaccinated compared with unvaccinated children after adjustment for confounders (OR, 1.03; 95% confidence interval, 0.72-1.48). The risk of atopy in BCG-vaccinated children was not associated with age at vaccination (P = .17). Conclusions: BCG vaccination administered to infants is not associated with reduced risk of development of atopy.

UR - http://www.scopus.com/inward/record.url?scp=0037466930&partnerID=8YFLogxK

U2 - 10.1001/jama.289.8.1012

DO - 10.1001/jama.289.8.1012

M3 - Journal article

C2 - 12597754

AN - SCOPUS:0037466930

VL - 289

SP - 1012

EP - 1015

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 8

ER -

ID: 247937036