Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency
Research output: Contribution to journal › Journal article › Research › peer-review
Immunosuppressive thiopurines like azathioprine, 6-mercaptopurine, and thioguanine are commonly used in inflammatory and neoplastic disorders. A subset of these patients are genetically slow metabolizers due to point-mutations in enzyme thiopurine S-methyltransferase (TPMT), and are at a higher risk of hematologic toxicity and leukemogenesis. We present such a patient who was a slow metabolizer for azathioprine, and developed a rapidly lethal form acute myeloid leukemia after relatively low dose exposure to the drug. There was prominent hemophagocytic activity in the bone marrow, and cytogenetic analysis showed a complex karyotype with monosomy 7, but no involvement of chromosome 8
Udgivelsesdato: 2008/1
Udgivelsesdato: 2008/1
Original language | English |
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Journal | American Journal of Hematology |
Volume | 83 |
Issue number | 1 |
Pages (from-to) | 80-83 |
Number of pages | 3 |
ISSN | 0361-8609 |
Publication status | Published - 2008 |
ID: 14302733