AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees
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AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees. / Mulholland, Michele M.; Navabpour, Shaghayegh V.; Mareno, Mary C.; Schapiro, Steven J.; Young, Larry J.; Hopkins, William D.
In: Genes, Brain and Behavior, Vol. 19, No. 4, e12631, 01.04.2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees
AU - Mulholland, Michele M.
AU - Navabpour, Shaghayegh V.
AU - Mareno, Mary C.
AU - Schapiro, Steven J.
AU - Young, Larry J.
AU - Hopkins, William D.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - The vasopressin system has been implicated in the regulation of social behavior and cognition in humans, nonhuman primates and other social mammals. In chimpanzees, polymorphisms in the vasopressin V1a receptor gene (AVPR1A) have been associated with social dimensions of personality, as well as to responses to sociocommunicative cues and mirror self-recognition. Despite evidence of this association with social cognition and behavior, there is little research on the neuroanatomical correlates of AVPR1A variation. In the current study, we tested the association between AVPR1A polymorphisms in the RS3 promotor region and gray matter covariation in chimpanzees using magnetic resonance imaging and source-based morphometry. The analysis identified 13 independent brain components, three of which differed significantly in covariation between the two AVPR1A genotypes (DupB−/− and DupB+/−; P <.05). DupB+/− chimpanzees showed greater covariation in gray matter in the premotor and prefrontal cortex, basal forebrain, lunate and cingulate cortex, and lesser gray matter covariation in the superior temporal sulcus and postcentral sulcus. Some of these regions were previously found to differ in vasopressin and oxytocin neural fibers between nonhuman primates, and in AVPR1A gene expression in humans with different RS3 alleles. This is the first report of an association between AVPR1A and gray matter covariation in nonhuman primates, and specifically links an AVPR1A polymorphism to structural variation in the social brain network. These results further affirm the value of chimpanzees as a model species for investigating the relationship between genetic variation, brain structure and social cognition with relevance to psychiatric disorders, including autism.
AB - The vasopressin system has been implicated in the regulation of social behavior and cognition in humans, nonhuman primates and other social mammals. In chimpanzees, polymorphisms in the vasopressin V1a receptor gene (AVPR1A) have been associated with social dimensions of personality, as well as to responses to sociocommunicative cues and mirror self-recognition. Despite evidence of this association with social cognition and behavior, there is little research on the neuroanatomical correlates of AVPR1A variation. In the current study, we tested the association between AVPR1A polymorphisms in the RS3 promotor region and gray matter covariation in chimpanzees using magnetic resonance imaging and source-based morphometry. The analysis identified 13 independent brain components, three of which differed significantly in covariation between the two AVPR1A genotypes (DupB−/− and DupB+/−; P <.05). DupB+/− chimpanzees showed greater covariation in gray matter in the premotor and prefrontal cortex, basal forebrain, lunate and cingulate cortex, and lesser gray matter covariation in the superior temporal sulcus and postcentral sulcus. Some of these regions were previously found to differ in vasopressin and oxytocin neural fibers between nonhuman primates, and in AVPR1A gene expression in humans with different RS3 alleles. This is the first report of an association between AVPR1A and gray matter covariation in nonhuman primates, and specifically links an AVPR1A polymorphism to structural variation in the social brain network. These results further affirm the value of chimpanzees as a model species for investigating the relationship between genetic variation, brain structure and social cognition with relevance to psychiatric disorders, including autism.
KW - AVPR1A
KW - brain structure
KW - chimpanzee
KW - gray matter
KW - vasopressin
U2 - 10.1111/gbb.12631
DO - 10.1111/gbb.12631
M3 - Journal article
C2 - 31894656
AN - SCOPUS:85077860182
VL - 19
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
SN - 1601-1848
IS - 4
M1 - e12631
ER -
ID: 259505177