Automatic detection and localization of bone erosion in hand HR-pQCT
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Rheumatoid arthritis (RA) is an inflammatory disease which afflicts the joints with arthritis and periarticular bone destruction as a result. One of its central features is bone erosion, a consequence of excessive bone resorption and insufficient bone formation. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a promising tool for monitoring RA. Quantification of bone erosions and detection of possible progression is essential in the management of treatment. Detection is performed manually and is a very demanding task as rheumatologists must annotate hundreds of 2D images and inspect any region of the bone structure that is suspected to be a sign of RA. We propose a 2D based method which combines an accurate segmentation of bone surface boundary and classification of patches along the surface as healthy or eroded. We use a series of classical image processing methods to segment CT volumes semi-automatically. They are used as training data for a U-Net. We train a Siamese net to learn the difference between healthy and eroded patches. The Siamese net alleviates the problem of highly imbalanced class labels by providing a base for one-shot learning of differences between patches. We trained and tested the method using 3 full HR-pQCT scans with bone erosion of various size. The proposed pipeline succeeded in classifying healthy and eroded patches with high precision and recall. The proposed algorithm is a preliminary work to demonstrate the potential of our pipeline in automating the process of detecting and locating the eroded regions of bone surfaces affected by RA.
Original language | English |
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Title of host publication | Medical Imaging 2019 : Computer-Aided Diagnosis |
Editors | Kensaku Mori, Horst K. Hahn |
Number of pages | 9 |
Publisher | SPIE - International Society for Optical Engineering |
Publication date | 2019 |
Article number | 1095022 |
ISBN (Electronic) | 9781510625471 |
DOIs | |
Publication status | Published - 2019 |
Event | Medical Imaging 2019: Computer-Aided Diagnosis - San Diego, United States Duration: 17 Feb 2019 → 20 Feb 2019 |
Conference
Conference | Medical Imaging 2019: Computer-Aided Diagnosis |
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Land | United States |
By | San Diego |
Periode | 17/02/2019 → 20/02/2019 |
Sponsor | The Society of Photo-Optical Instrumentation Engineers (SPIE) |
Series | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
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Volume | 10950 |
ISSN | 1605-7422 |
- Active Contours, Bone Erosion, HR-pQCT, Rheumatoid Arthritis, Siamese Nets, U-Nets
Research areas
ID: 227331677