Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens
Research output: Contribution to journal › Journal article › Research › peer-review
A new asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens has been found. Although alcohols are not the natural substrates for this enzyme, a high R enantioselectivity was observed. Stereochemical studies showed that variations in substrate structure lead to strong variations in enantioselectivity. The highest enantioselectivities are obtained when the β-carbon of the secondary alcohol is tertiary or quaternary.
| Original language | English |
|---|---|
| Journal | Bioorganic Chemistry |
| Volume | 33 |
| Issue number | 4 |
| Pages (from-to) | 325-337 |
| Number of pages | 13 |
| ISSN | 0045-2068 |
| DOIs | |
| Publication status | Published - 2005 |
| Externally published | Yes |
Bibliographical note
Funding Information:
We thank the Greek Secretariat of Research and Technology (PENED 2001) and the Ministry of Education (B-EPEAEK graduate program) for financial support and graduate fellowship to N.S.H.
- Enantioselectivity, Ferulic acid, Feruloyl esterase, Humicola insolens, Secondary alcohols, Transesterification
Research areas
ID: 286412469