TY - JOUR

T1 - Association of patient-reported pain with survival in bladder cancer

T2 - a post-hoc analysis of the iBLAD trial

AU - Stormoen, Dag Rune

AU - Taarnhøj, Gry Assam

AU - Friis, Rasmus Blechingberg

AU - Johansen, Christoffer

AU - Pappot, Helle

N1 - Funding Information: The iBLAD study and this post-hoc analysis was funded by The Danish Cancer Society, Dagmar Marshalls Fond, Einar Willumsens Mindelegat, A.P. Møller Lægefonden, Christian Larsen og Dommer Ellen Larsens Legat, Rigshospitalets Fond til støtte for onkologiske formaal, Onkologisk Forskningsfond and Rigshospitalets Jubilæumsfond, Fabrikant Einar Willumsens Mindelegat; Kræftens Bekæmpelse. None of the funding sources played a role in the planning, conduction of the study, analyses of the data or writing of the manuscript. We thank the statisticians at the Section of Biostatistics at University of Copenhagen for assisting with the formal analysis.

PY - 2023

Y1 - 2023

N2 - This post-hoc analysis of the iBLAD trial investigates the association of patient-reported symptoms with survival in bladder cancer (BC) patients during and after oncological treatment.Patient-reported outcomes (PRO) are increasingly being used in clinical and research settings to assess self-reported symptoms during oncological treatment [Citation1,Citation2]. The FDA and EMA recommend the inclusion of PROs in all clinical research studies [Citation3,Citation4]. Furthermore, the active use of PROs compared to standard care for symptom-handling during cancer therapy has been shown to improve QoL and even survival [Citation5,Citation6]. More studies have demonstrated how PROs can be used as a complementary tool to assess, monitor and manage symptoms during oncological treatment [Citation7–10].Several studies have also shown that patient-reported outcome measures can serve as a prognostic tool [Citation6,Citation9,Citation11–13]. PRO measures associated with decreased survival include fatigue, global health, quality of life, pain, loss of appetite and physical function [Citation6,Citation9,Citation11,Citation13–15].This study aims to evaluate the prognostic significance of patient self-reported symptom scores using the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE, henceforth PRO) and secondly to identify symptoms associated with reduced survival in BC.

AB - This post-hoc analysis of the iBLAD trial investigates the association of patient-reported symptoms with survival in bladder cancer (BC) patients during and after oncological treatment.Patient-reported outcomes (PRO) are increasingly being used in clinical and research settings to assess self-reported symptoms during oncological treatment [Citation1,Citation2]. The FDA and EMA recommend the inclusion of PROs in all clinical research studies [Citation3,Citation4]. Furthermore, the active use of PROs compared to standard care for symptom-handling during cancer therapy has been shown to improve QoL and even survival [Citation5,Citation6]. More studies have demonstrated how PROs can be used as a complementary tool to assess, monitor and manage symptoms during oncological treatment [Citation7–10].Several studies have also shown that patient-reported outcome measures can serve as a prognostic tool [Citation6,Citation9,Citation11–13]. PRO measures associated with decreased survival include fatigue, global health, quality of life, pain, loss of appetite and physical function [Citation6,Citation9,Citation11,Citation13–15].This study aims to evaluate the prognostic significance of patient self-reported symptom scores using the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE, henceforth PRO) and secondly to identify symptoms associated with reduced survival in BC.

U2 - 10.1080/0284186X.2023.2199461

DO - 10.1080/0284186X.2023.2199461

M3 - Letter

C2 - 37071772

AN - SCOPUS:85153374920

VL - 62

SP - 814

EP - 819

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1100-1704

IS - 7

ER -