Are Self-disorders in Schizophrenia Expressive of a Unifying Disturbance of Subjectivity: A Factor Analytic Approach
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Are Self-disorders in Schizophrenia Expressive of a Unifying Disturbance of Subjectivity : A Factor Analytic Approach. / Nordgaard, Julie; Berge, Jonas; Rasmussen, Andreas Rosen; Sandsten, Karl Erik; Zandersen, Maja; Parnas, Josef.
In: Schizophrenia Bulletin, Vol. 49, No. 1, 2023, p. 144–150.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Are Self-disorders in Schizophrenia Expressive of a Unifying Disturbance of Subjectivity
T2 - A Factor Analytic Approach
AU - Nordgaard, Julie
AU - Berge, Jonas
AU - Rasmussen, Andreas Rosen
AU - Sandsten, Karl Erik
AU - Zandersen, Maja
AU - Parnas, Josef
PY - 2023
Y1 - 2023
N2 - Background and Hypothesis The idea that a disorder of the basic self is a central feature in schizophrenia has recently been corroborated in a meta-analysis and a systematic review. Manifestations of the self-disorder can be systematically explored with the Examination of Anomalous Self-Experience (EASE). In this study, we examined the factorial structure of EASE, and diagnostic efficacy of EASE. We hypothesized that EASE will have a monofactorial structure as an instability of the basic self will result in multiple deformations of self-experience which would be meaningfully interrelated as aspects of a unifying Gestalt. Design EASE data for 226 patients suffering from various mental disorders were analyzed under a confirmatory factor analysis framework (CFA). Area under the receiver operating characteristic curve (AUC) was calculated for the total EASE sums, and sensitivity and specificity values for prediction of schizophrenia spectrum disorders based on different cut-offs were obtained. Results Fit indices for the CFA model: RMSEA = 0.036, SRMR = 0.100, CFI = 0.983, TLI = 0.981. The AUC value was 0.946 (95% confidence interval: 0.919-0.974). Sensitivity as well as specificity for schizophrenia spectrum disorders were high. Conclusion Our results lend support for EASE exhibiting a monofactorial structure and the notion of self-disorders as a central phenotypic feature of schizophrenia spectrum disorders.
AB - Background and Hypothesis The idea that a disorder of the basic self is a central feature in schizophrenia has recently been corroborated in a meta-analysis and a systematic review. Manifestations of the self-disorder can be systematically explored with the Examination of Anomalous Self-Experience (EASE). In this study, we examined the factorial structure of EASE, and diagnostic efficacy of EASE. We hypothesized that EASE will have a monofactorial structure as an instability of the basic self will result in multiple deformations of self-experience which would be meaningfully interrelated as aspects of a unifying Gestalt. Design EASE data for 226 patients suffering from various mental disorders were analyzed under a confirmatory factor analysis framework (CFA). Area under the receiver operating characteristic curve (AUC) was calculated for the total EASE sums, and sensitivity and specificity values for prediction of schizophrenia spectrum disorders based on different cut-offs were obtained. Results Fit indices for the CFA model: RMSEA = 0.036, SRMR = 0.100, CFI = 0.983, TLI = 0.981. The AUC value was 0.946 (95% confidence interval: 0.919-0.974). Sensitivity as well as specificity for schizophrenia spectrum disorders were high. Conclusion Our results lend support for EASE exhibiting a monofactorial structure and the notion of self-disorders as a central phenotypic feature of schizophrenia spectrum disorders.
KW - self-disorders
KW - selfhood
KW - basic self
KW - sensitivity
KW - specificity
KW - cut-off
KW - schizophrenia
KW - monofactorial
KW - PSYCHIATRIC INTERVIEW
KW - EXPERIENCE
U2 - 10.1093/schbul/sbac123
DO - 10.1093/schbul/sbac123
M3 - Journal article
C2 - 36073251
VL - 49
SP - 144
EP - 150
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 1
ER -
ID: 319649040