Are microRNAs located in genomic regions associated with cancer?
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Are microRNAs located in genomic regions associated with cancer? / Lamy, P.; Andersen, C. L.; Dyrskjøt, L.; Tørring, N.; Ørntoft, T.; Wiuf, C.
In: British Journal of Cancer, Vol. 95, No. 10, 20.11.2006, p. 1415-1418.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Are microRNAs located in genomic regions associated with cancer?
AU - Lamy, P.
AU - Andersen, C. L.
AU - Dyrskjøt, L.
AU - Tørring, N.
AU - Ørntoft, T.
AU - Wiuf, C.
PY - 2006/11/20
Y1 - 2006/11/20
N2 - We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.
AB - We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.
KW - Affymetrix SNP array
KW - Bladder
KW - Colon
KW - Copy number
KW - microRNA
KW - Prostate
UR - http://www.scopus.com/inward/record.url?scp=33751069186&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6603381
DO - 10.1038/sj.bjc.6603381
M3 - Journal article
C2 - 17003783
AN - SCOPUS:33751069186
VL - 95
SP - 1415
EP - 1418
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
IS - 10
ER -
ID: 203903795