Amphotericin B and the blood-brain barrier to methotrexate
Research output: Contribution to journal › Journal article › Research › peer-review
The permeability of the blood-brain barrier (BBB) to methotrexate, Na+, and Cl- was studied in rats treated with the membrane-active antifungal agent amphotericin B. Enhancement of brain uptake of methotrexate was expected as amphotericin B increases the permeability of lipid membranes, including tumor cell membranes. However, amphotericin B had no effect of the BBB permeability to methotrexate, Na+, and Cl-. This may have been because the amphotericin B acted only on the luminal and not on the abluminal brain capillary membrane, leaving the BBB intact.
Original language | English |
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Journal | Neurosurgery |
Volume | 10 |
Issue number | 2 |
Pages (from-to) | 224-6 |
Number of pages | 3 |
ISSN | 0148-396X |
Publication status | Published - Feb 1982 |
- Amphotericin B/pharmacology, Animals, Antineoplastic Agents/administration & dosage, Blood-Brain Barrier/drug effects, Brain Neoplasms/drug therapy, Chlorides/metabolism, Drug Therapy, Combination, Male, Methotrexate/metabolism, Rats, Rats, Inbred Strains, Sodium/metabolism
Research areas
ID: 279596784