Albiglutide for treating type 2 diabetes: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy
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Albiglutide for treating type 2 diabetes : an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy. / Brønden, Andreas; Naver, Signe V.; Knop, Filip K.; Christensen, Mikkel.
In: Expert Opinion on Drug Metabolism & Toxicology, Vol. 11, No. 9, 2015, p. 1493-1503.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Albiglutide for treating type 2 diabetes
T2 - an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy
AU - Brønden, Andreas
AU - Naver, Signe V.
AU - Knop, Filip K.
AU - Christensen, Mikkel
PY - 2015
Y1 - 2015
N2 - INTRODUCTION: Albiglutide is a once-weekly, glucagon-like peptide-1 receptor agonist approved during 2014 in both the US and Europe for the treatment of adults with type 2 diabetes. The recommended dose is 30 mg with the possibility of uptitration to 50 mg based on individual glycemic response.AREAS COVERED: Here, we outline the pharmacokinetics, pharmacodynamics and clinical efficacy data originating from the Phase I - III studies carried out to obtain market authorization for albiglutide.EXPERT OPINION: The eight Phase III clinical trials have provided evidence that albiglutide in monotherapy and as an add-on to different background therapies confers placebo-corrected reductions in glycemia with changes in glycated hemoglobin of -0.8 to -1.0%. Albiglutide did not cause significant weight loss compared to placebo, but the adverse events profile was favorable with gastrointestinal adverse events occurring only slightly more with albiglutide than placebo. There is no clinical evidence of an effect of albiglutide on major cardiovascular outcomes.
AB - INTRODUCTION: Albiglutide is a once-weekly, glucagon-like peptide-1 receptor agonist approved during 2014 in both the US and Europe for the treatment of adults with type 2 diabetes. The recommended dose is 30 mg with the possibility of uptitration to 50 mg based on individual glycemic response.AREAS COVERED: Here, we outline the pharmacokinetics, pharmacodynamics and clinical efficacy data originating from the Phase I - III studies carried out to obtain market authorization for albiglutide.EXPERT OPINION: The eight Phase III clinical trials have provided evidence that albiglutide in monotherapy and as an add-on to different background therapies confers placebo-corrected reductions in glycemia with changes in glycated hemoglobin of -0.8 to -1.0%. Albiglutide did not cause significant weight loss compared to placebo, but the adverse events profile was favorable with gastrointestinal adverse events occurring only slightly more with albiglutide than placebo. There is no clinical evidence of an effect of albiglutide on major cardiovascular outcomes.
KW - Adult
KW - Clinical Trials, Phase I as Topic
KW - Clinical Trials, Phase II as Topic
KW - Clinical Trials, Phase III as Topic
KW - Diabetes Mellitus, Type 2
KW - Dose-Response Relationship, Drug
KW - Glucagon-Like Peptide 1
KW - Glucagon-Like Peptide-1 Receptor
KW - Humans
KW - Hypoglycemic Agents
KW - Weight Loss
U2 - 10.1517/17425255.2015.1068288
DO - 10.1517/17425255.2015.1068288
M3 - Journal article
C2 - 26166682
VL - 11
SP - 1493
EP - 1503
JO - Expert Opinion on Drug Metabolism and Toxicology
JF - Expert Opinion on Drug Metabolism and Toxicology
SN - 1742-5255
IS - 9
ER -
ID: 162685299