Adverse events in transcatheter interventions for congenital heart disease: a population-based long-term study
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Adverse events in transcatheter interventions for congenital heart disease : a population-based long-term study. / Larsen, Signe Holm; Emmertsen, Kristian; Hjortdal, Vibeke Elisabeth; Nielsen-Kudsk, Jens Erik.
In: Congenital Heart Disease, Vol. 10, No. 2, 10.09.2014, p. 153-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Adverse events in transcatheter interventions for congenital heart disease
T2 - a population-based long-term study
AU - Larsen, Signe Holm
AU - Emmertsen, Kristian
AU - Hjortdal, Vibeke Elisabeth
AU - Nielsen-Kudsk, Jens Erik
N1 - © 2014 Wiley Periodicals, Inc.
PY - 2014/9/10
Y1 - 2014/9/10
N2 - OBJECTIVE: Few studies have reported procedure complications or adverse events for transcatheter interventions in unselected congenital heart disease cohorts. We report our 23-year experience with transcatheter interventions in congenital heart disease and examine predictors for adverse events.DESIGN AND SETTING: This study was a population-based cohort study of children and adults with congenital heart disease, covering a population of 3 million inhabitants in western Denmark. Adverse events were subdivided into 5 levels according to their severity. Procedure-type risk category, age, weight, and year of procedure were included in multivariate logistic models to identify risk factors for adverse events.RESULTS: Between 1990 and 2012, 1595 patients had 1878 catheter-based interventions performed. We identified 241 adverse events, corresponding to 13% of the procedures; 58 (3%) were considered to be of high severity. During the study period, there was an increase in number of procedures per year (P < .001) and a decrease in frequency of adverse events (P = .01). Procedure-type categories 3 and 4 had increased risk of adverse events when compared with category 2, with odds ratios of 1.7 (95% confidence interval [CI]: 1.2-2.3) for category 3 and 2.3 for category 4 (95% CI: 1.4-3.6). Age and weight at catheterization were not independently associated with adverse events.CONCLUSIONS: We found an increase in number of procedures over time and a decrease in frequency of adverse events. Higher procedure-type risk categories were associated with increased risk of adverse events.
AB - OBJECTIVE: Few studies have reported procedure complications or adverse events for transcatheter interventions in unselected congenital heart disease cohorts. We report our 23-year experience with transcatheter interventions in congenital heart disease and examine predictors for adverse events.DESIGN AND SETTING: This study was a population-based cohort study of children and adults with congenital heart disease, covering a population of 3 million inhabitants in western Denmark. Adverse events were subdivided into 5 levels according to their severity. Procedure-type risk category, age, weight, and year of procedure were included in multivariate logistic models to identify risk factors for adverse events.RESULTS: Between 1990 and 2012, 1595 patients had 1878 catheter-based interventions performed. We identified 241 adverse events, corresponding to 13% of the procedures; 58 (3%) were considered to be of high severity. During the study period, there was an increase in number of procedures per year (P < .001) and a decrease in frequency of adverse events (P = .01). Procedure-type categories 3 and 4 had increased risk of adverse events when compared with category 2, with odds ratios of 1.7 (95% confidence interval [CI]: 1.2-2.3) for category 3 and 2.3 for category 4 (95% CI: 1.4-3.6). Age and weight at catheterization were not independently associated with adverse events.CONCLUSIONS: We found an increase in number of procedures over time and a decrease in frequency of adverse events. Higher procedure-type risk categories were associated with increased risk of adverse events.
KW - Adolescent
KW - Cardiac Catheterization/adverse effects
KW - Cardiac Surgical Procedures/adverse effects
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Female
KW - Heart Defects, Congenital/surgery
KW - Heart Diseases/congenital
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Postoperative Complications/epidemiology
KW - Prognosis
KW - Retrospective Studies
KW - Time Factors
U2 - 10.1111/chd.12218
DO - 10.1111/chd.12218
M3 - Journal article
C2 - 25196278
VL - 10
SP - 153
EP - 158
JO - Congenital Heart Disease
JF - Congenital Heart Disease
SN - 1747-079X
IS - 2
ER -
ID: 242611344