Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding
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Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding. / Foreman, Amy L.; Warth, Benedikt; Hessel, Ellen V.S.; Price, Elliott J.; Schymanski, Emma L.; Cantelli, Gaia; Parkinson, Helen; Hecht, Helge; Klánová, Jana; Vlaanderen, Jelle; Hilscherova, Klara; Vrijheid, Martine; Vineis, Paolo; Araujo, Rita; Barouki, Robert; Vermeulen, Roel; Lanone, Sophie; Brunak, Søren; Sebert, Sylvain; Karjalainen, Tuomo.
In: Environmental Science and Technology, Vol. 58, No. 17, 2024, p. 7256-7269.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding
AU - Foreman, Amy L.
AU - Warth, Benedikt
AU - Hessel, Ellen V.S.
AU - Price, Elliott J.
AU - Schymanski, Emma L.
AU - Cantelli, Gaia
AU - Parkinson, Helen
AU - Hecht, Helge
AU - Klánová, Jana
AU - Vlaanderen, Jelle
AU - Hilscherova, Klara
AU - Vrijheid, Martine
AU - Vineis, Paolo
AU - Araujo, Rita
AU - Barouki, Robert
AU - Vermeulen, Roel
AU - Lanone, Sophie
AU - Brunak, Søren
AU - Sebert, Sylvain
AU - Karjalainen, Tuomo
N1 - Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.
PY - 2024
Y1 - 2024
N2 - Through investigating the combined impact of the environmental exposures experienced by an individual throughout their lifetime, exposome research provides opportunities to understand and mitigate negative health outcomes. While current exposome research is driven by epidemiological studies that identify associations between exposures and effects, new frameworks integrating more substantial population-level metadata, including electronic health and administrative records, will shed further light on characterizing environmental exposure risks. Molecular biology offers methods and concepts to study the biological and health impacts of exposomes in experimental and computational systems. Of particular importance is the growing use of omics readouts in epidemiological and clinical studies. This paper calls for the adoption of mechanistic molecular biology approaches in exposome research as an essential step in understanding the genotype and exposure interactions underlying human phenotypes. A series of recommendations are presented to make the necessary and appropriate steps to move from exposure association to causation, with a huge potential to inform precision medicine and population health. This includes establishing hypothesis-driven laboratory testing within the exposome field, supported by appropriate methods to read across from model systems research to human.
AB - Through investigating the combined impact of the environmental exposures experienced by an individual throughout their lifetime, exposome research provides opportunities to understand and mitigate negative health outcomes. While current exposome research is driven by epidemiological studies that identify associations between exposures and effects, new frameworks integrating more substantial population-level metadata, including electronic health and administrative records, will shed further light on characterizing environmental exposure risks. Molecular biology offers methods and concepts to study the biological and health impacts of exposomes in experimental and computational systems. Of particular importance is the growing use of omics readouts in epidemiological and clinical studies. This paper calls for the adoption of mechanistic molecular biology approaches in exposome research as an essential step in understanding the genotype and exposure interactions underlying human phenotypes. A series of recommendations are presented to make the necessary and appropriate steps to move from exposure association to causation, with a huge potential to inform precision medicine and population health. This includes establishing hypothesis-driven laboratory testing within the exposome field, supported by appropriate methods to read across from model systems research to human.
KW - Environment
KW - Exposome
KW - Exposure
KW - GxE
KW - Human Health
KW - Molecular Biology
KW - Toxicology
U2 - 10.1021/acs.est.3c07961
DO - 10.1021/acs.est.3c07961
M3 - Review
C2 - 38641325
AN - SCOPUS:85191174239
VL - 58
SP - 7256
EP - 7269
JO - Environmental Science & Technology
JF - Environmental Science & Technology
SN - 0013-936X
IS - 17
ER -
ID: 393273475