ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy
Research output: Contribution to journal › Journal article › Research › peer-review
We have recently shown that overexpression of ADAM12 results in increased muscle regeneration and significantly reduced pathology in mdx, dystrophin deficient mice. In the present study, we tested the effect of overexpressing ADAM12 in dy(W) laminin-deficient mice. dy mice have a very severe clinical phenotype and would be expected to benefit greatly from enhanced regeneration. We found that dy(W) mice overexpressing ADAM12 indeed have increased muscle regeneration, as evidenced by increased numbers of muscle fibers expressing fetal myosin. However, overexpression of ADAM12 had no significant effect on overall health, as evidenced by body weight, and did not improve muscle pathology.
Original language | English |
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Journal | Neuromuscular Disorders |
Volume | 15 |
Issue number | 11 |
Pages (from-to) | 786-9 |
Number of pages | 4 |
ISSN | 0960-8966 |
DOIs | |
Publication status | Published - 1 Nov 2005 |
- ADAM Proteins, Age Factors, Animals, Blotting, Western, Body Weight, Disease Models, Animal, Gene Expression Regulation, Immunohistochemistry, Laminin, Mice, Mice, Knockout, Muscular Dystrophy, Animal, Regeneration
Research areas
ID: 34325158