Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia. / Lambert, I. H.; Pedersen, S. F.; Poulsen, K. A.

In: Acta Physiologica (Print Edition), Vol. 187, No. 1-2, 2006, p. 75-85.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lambert, IH, Pedersen, SF & Poulsen, KA 2006, 'Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia', Acta Physiologica (Print Edition), vol. 187, no. 1-2, pp. 75-85. https://doi.org/10.1111/j.1748-1716.2006.01557.x

APA

Lambert, I. H., Pedersen, S. F., & Poulsen, K. A. (2006). Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia. Acta Physiologica (Print Edition), 187(1-2), 75-85. https://doi.org/10.1111/j.1748-1716.2006.01557.x

Vancouver

Lambert IH, Pedersen SF, Poulsen KA. Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia. Acta Physiologica (Print Edition). 2006;187(1-2):75-85. https://doi.org/10.1111/j.1748-1716.2006.01557.x

Author

Lambert, I. H. ; Pedersen, S. F. ; Poulsen, K. A. / Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia. In: Acta Physiologica (Print Edition). 2006 ; Vol. 187, No. 1-2. pp. 75-85.

Bibtex

@article{4dc094e06c3711dcbee902004c4f4f50,

title = "Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia",

abstract = "Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition.",

author = "Lambert, {I. H.} and Pedersen, {S. F.} and Poulsen, {K. A.}",

note = "KEYWORDS arachidonic acid • F-actin • Ca2+-independent phospholipase A2 • ischaemia • organic osmolytes • phospholipase A2 • reactive oxygen species",

year = "2006",

doi = "10.1111/j.1748-1716.2006.01557.x",

language = "English",

volume = "187",

pages = "75--85",

journal = "Acta Physiologica",

issn = "1748-1708",

publisher = "Wiley-Blackwell",

number = "1-2",

}

RIS

TY - JOUR

T1 - Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia

AU - Lambert, I. H.

AU - Pedersen, S. F.

AU - Poulsen, K. A.

N1 - KEYWORDS arachidonic acid • F-actin • Ca2+-independent phospholipase A2 • ischaemia • organic osmolytes • phospholipase A2 • reactive oxygen species

PY - 2006

Y1 - 2006

N2 - Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition.

AB - Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition.

U2 - 10.1111/j.1748-1716.2006.01557.x

DO - 10.1111/j.1748-1716.2006.01557.x

M3 - Journal article

VL - 187

SP - 75

EP - 85

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 1-2

ER -

ID: 1100461