Acetaminophen induced antioxidant and detoxification responses in a stygobitic crustacean
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Acetaminophen induced antioxidant and detoxification responses in a stygobitic crustacean. / Duarte, Cláudia; Gravato, Carlos; Di Lorenzo, Tiziana; Reboleira, Ana Sofia P. S.
In: Environmental Pollution, Vol. 330, 121749, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Acetaminophen induced antioxidant and detoxification responses in a stygobitic crustacean
AU - Duarte, Cláudia
AU - Gravato, Carlos
AU - Di Lorenzo, Tiziana
AU - Reboleira, Ana Sofia P. S.
N1 - Publisher Copyright: © 2023 Elsevier Ltd
PY - 2023
Y1 - 2023
N2 - A variety of veterinary and human medicinal products (VHMPs) are found in groundwater, an often-neglected habitat inhabited by species with unique traits, stygobitic species. It is crucial to understand the effect of VHMPs on stygobitic species because they may respond differently to stressors than surface species. Our hypothesis is that groundwater species may be more susceptible to environmental contaminants due to less plasticity in their detoxification response and acquisition of energy because subterranean habitats are more stable and isolated from anthropogenic activities. We performed a battery of biomarkers associated with important physiological functions on the stygobitic asellid crustacean Proasellus lusitanicus, after a 14-day exposure to acetaminophen, a commonly used pharmaceutical and pollutant of groundwaters. Our results show a decrease in total glutathione levels and an increase in glutathione S-transferase activity, suggesting a successful detoxification response. This helps explaining why acetaminophen did not cause oxidative damage, as well as had no effect on cholinesterase activity nor in aerobic production of energy. This study shows the remarkable capacity of P. lusitanicus to tolerate sublethal concentrations of VHMP acetaminophen. Most ecotoxicological studies on stygobitic species focused on the lethal effects of these compounds. The present study focuses on consequences at sublethal concentrations. Future studies should assess the stress levels induced to better predict and estimate the impacts of contaminants on groundwater ecosystems.
AB - A variety of veterinary and human medicinal products (VHMPs) are found in groundwater, an often-neglected habitat inhabited by species with unique traits, stygobitic species. It is crucial to understand the effect of VHMPs on stygobitic species because they may respond differently to stressors than surface species. Our hypothesis is that groundwater species may be more susceptible to environmental contaminants due to less plasticity in their detoxification response and acquisition of energy because subterranean habitats are more stable and isolated from anthropogenic activities. We performed a battery of biomarkers associated with important physiological functions on the stygobitic asellid crustacean Proasellus lusitanicus, after a 14-day exposure to acetaminophen, a commonly used pharmaceutical and pollutant of groundwaters. Our results show a decrease in total glutathione levels and an increase in glutathione S-transferase activity, suggesting a successful detoxification response. This helps explaining why acetaminophen did not cause oxidative damage, as well as had no effect on cholinesterase activity nor in aerobic production of energy. This study shows the remarkable capacity of P. lusitanicus to tolerate sublethal concentrations of VHMP acetaminophen. Most ecotoxicological studies on stygobitic species focused on the lethal effects of these compounds. The present study focuses on consequences at sublethal concentrations. Future studies should assess the stress levels induced to better predict and estimate the impacts of contaminants on groundwater ecosystems.
KW - Biomarkers
KW - Groundwater
KW - Oxidative stress
KW - Sublethal effects
KW - Subterranean ecosystems
U2 - 10.1016/j.envpol.2023.121749
DO - 10.1016/j.envpol.2023.121749
M3 - Journal article
C2 - 37127234
AN - SCOPUS:85153946170
VL - 330
JO - Environmental Pollution
JF - Environmental Pollution
SN - 0269-7491
M1 - 121749
ER -
ID: 346412197